Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial.
Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial.
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DOI：
10.1186/1745-6215-12-67
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发表时间：
2011-03-07
期刊：
影响因子：
2.5
通讯作者：
Karim SS
中科院分区：
文献类型：
--
作者：
Karim QA;Kharsany AB;Frohlich JA;Baxter C;Yende N;Mansoor LE;Mlisana KP;Maarschalk S;Arulappan N;Grobler A;Sibeko S;Omar Z;Gengiah TN;Mlotshwa M;Samsunder N;Karim SS
与男子相比，撒哈拉以南非洲的年轻妇女承受着不成比例的艾滋病毒感染负担，但降低艾滋病毒风险的选择有限。杀菌剂可以填补性行为活跃的妇女预防艾滋病毒的一个重要空白，这些妇女无法成功地谈判双方的一夫一妻制或使用避孕套。本文描述了CAPRISA 004试验中的基线样本特征，该试验评估了1%替诺福韦凝胶在南非预防艾滋病毒的阴道杀菌剂的安全性和有效性。这项分析评估了经过筛选并加入试验的女性的基线人口统计、临床和性行为数据。使用描述性汇总措施对这些特征进行了总结；以分类变量的平均值和百分比表示。筛查时艾滋病毒感染率为25.8%[95%可信区间：23.9-27.7]。在提供随访数据的889名符合条件的登记妇女中，从计划生育诊所招募的农村参与者更年轻，更有可能与正常伴侣分开居住，报告的性交频率较低，避孕套使用率较低(p<；0.001)。相比之下，从性传播疾病诊所招募的城市参与者报告称，他们的终身性伴侣、最近30天内的新伴侣以及以性行为换取金钱的人数较多(P<；0.001)。选定的人群为艾滋病毒预防干预研究提供了合适的多样化目标群体。临床试验网站：nct 00441298
Young women in sub-Saharan Africa bear a disproportionate burden of HIV infection compared to men but have limited options to reduce their HIV risk. Microbicides could fill an important HIV prevention gap for sexually active women who are unable to successfully negotiate mutual monogamy or condom use. This paper describes the baseline sample characteristics in the CAPRISA 004 trial which assessed the safety and effectiveness of the vaginal microbicide, 1% tenofovir gel for HIV prevention in South Africa. This analysis assessed the baseline demographic, clinical and sexual behavior data of women screened and enrolled into the trial. The characteristics were summarized using descriptive summary measures; expressed as means and percent for categorical variables. HIV prevalence at screening was 25.8% [95% Confidence Interval (CI):23.9-27.7). Of the 889 eligibly enrolled women who contributed follow-up data, rural participants recruited from a family planning (FP) clinic were younger, more likely to be living apart from their regular partner, reported lower coital frequency, had lower condom use (p < 0.001). In contrast, urban participants recruited from a sexually transmitted disease (STD) clinic reported higher numbers of lifetime sexual partners, new partners in the last 30 days and receiving money in exchange for sex (p < 0.001). The populations selected provide suitable diverse target groups for HIV prevention intervention studies. ClinicalTrials.gov: NCT 00441298
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DOI：
10.1097/01.aids.0000327431.82795.49
发表时间：
2008-08
期刊：
AIDS (London, England)
影响因子：
--
作者：
Collins C;Coates TJ;Curran J
通讯作者：
Curran J
影响因子：
3.8
作者：
Barnighausen, Till;Tanser, Frank;Newell, Marie-Louise
通讯作者：
Newell, Marie-Louise
影响因子：
3.7
作者：
van Loggerenberg F;Mlisana K;Williamson C;Auld SC;Morris L;Gray CM;Abdool Karim Q;Grobler A;Barnabas N;Iriogbe I;Abdool Karim SS;CAPRISA 002 Acute Infection Study Team
通讯作者：
CAPRISA 002 Acute Infection Study Team
影响因子：
158.5
作者：
Van Damme, Lut;Govinden, Roshini;Taylor, Doug
通讯作者：
Taylor, Doug
DOI：
10.1126/science.1193748
发表时间：
2010-09-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abdool Karim Q;Abdool Karim SS;Frohlich JA;Grobler AC;Baxter C;Mansoor LE;Kharsany AB;Sibeko S;Mlisana KP;Omar Z;Gengiah TN;Maarschalk S;Arulappan N;Mlotshwa M;Morris L;Taylor D;CAPRISA 004 Trial Group
通讯作者：
CAPRISA 004 Trial Group