Mesothelioma in a Worker Who Spun Chrysotile Asbestos at Home During Childhood
Mesothelioma in a Worker Who Spun Chrysotile Asbestos at Home During Childhood
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DOI：
10.1002/ajim.20675
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发表时间：
2009-04-01
影响因子：
3.5
通讯作者：
Suzuki, Yasunosuke
中科院分区：
文献类型：
--
作者：
Yano, Eiji;Wang, Zhi-Ming;Suzuki, Yasunosuke
背景：恶性间皮瘤潜伏期长，在角闪洞暴露者比温石棉暴露者更常见。方法重庆市某石棉纺织厂石棉工人，35岁，入职4年后患间皮瘤。他出生和成长在石棉厂的公司住宅，并在上学时手工纺石棉线。在该厂，没有使用角闪石，只使用了温石棉。结果经大体外观、组织学、组织化学、免疫细胞化学等综合检查证实了恶性间皮瘤的诊断。在肺和肿瘤组织中，尽管在工作环境中比例相反，但仍观察到大量的透闪石和异常的温石棉。住宅暴露和家庭纺石棉似乎有助于这个主题的间皮瘤的早期发展。虽然只使用了温石棉，而且工作环境中透闪石的污染也很低，但温石棉似乎被清除了，在组织中留下了透闪石。结论温石棉污染轻微的透闪石可导致恶性间皮瘤的早期发展。透闪石保留在肺组织中的机制有多种，其数量远远超过温石棉。点。中华医学杂志，2009,32(2):522 - 522。(C) 2009 Wiley-Liss, Inc。
Background Malignant mesothelioma has a long latency period and more commonly found in those exposed to amphibole than chrysotile asbestos.Method A 35 years old asbestos worker in an asbestos textile plant in Chongqing, China, developed mesothelioma after only 4 years of employment. He was born and bred in a company residence of an asbestos plant and manually spun asbestos thread during school age. In the plant, not amphibole but only chrysotile has been used.Results Diagnosis of malignant mesothelioma was confirmed by comprehensive approaches including gross appearance, histology, histochemistry, and immunocytochemistry. In the lung and tumor tissues, huge number of tremolite with exceptional chrysotile was observed despite the reverse proportion in the work environment.Discussion Residential exposure and home spinning of asbestos seemed contributed to the early development of mesothelioma in this subject. Although only chrysotile was used and contamination of tremolite was low in the work environment, chrysotile seemed to be cleared leaving tremolite remain in the tissue.Conclusion Chrysotile with little contamination of tremolite can lead to early development of malignant mesothelioma when heavily exposed from childhood at a company residence with household exposure. There can be several mechanisms for tremolite to remain in the lung tissue, far exceeding chrysotile in number. Am. J. Ind. Med. 52:282287, 2009. (C) 2009 Wiley-Liss, Inc.