Clinical comparison of pharmacologic emetics in children.
Clinical comparison of pharmacologic emetics in children.
复制标题
儿童药物催吐的临床比较。
作者：
Donald C. Corby;Walter J. Decker;Martin J. Moran;C. Payne
本文提出了一种简单的方法，通过测定胃内容物回流的效率，来确定药物催吐剂在儿童中的疗效。从该研究中可以得出以下结论：（a）阿扑吗啡可以由辅助医务人员安全地给药，（B）它与以前所担心的显著的CNS抑制或持久的呕吐无关，（c）它比吐根糖浆作用更快，和（d）它在从胃中除去试验物质方面与吐根糖浆同样有效。然而，从这项研究中可以明显看出，这两种药物在清除胃内容物方面都不是真正有效或可预测的，因此应该寻找一种更有效的治疗急性消化不良的方法。在找到更有效的方法之前，建议在家中使用吐根糖浆作为急救措施，在急诊室使用阿扑吗啡。
A simple method has been developed for the determination of the efficacy of pharmacologic emetic agents in children based on measuring the efficiency of stomach content return. The following conclusions can be reached from the study: (a) apomorphine can be safely administered by paramedical personnel, (b) it is not associated with significant CNS depression or protracted vomiting as has previously been feared, (c) it is faster acting than syrup of ipecac, and (d) it is equally effective in removing test material from the stomach as syrup of ipecac. However, it is apparent from this investigation that neither agent is truly effective or predictable in removing stomach contents, hence a search should be made for a more efficacious means of treating acute ingestions. Until more effective methods are found, it is recommended that syrup of ipecac be used as a first-aid measure in the home, and apomorphine be used in the emergency room.