Intrauterine programming of adult body composition
Intrauterine programming of adult body composition
复制标题
DOI：
10.1210/jc.86.1.267
复制
发表时间：
2001-01-01
影响因子：
5.8
通讯作者：
Cooper, C
中科院分区：
文献类型：
--
作者：
Gale, CR;Martyn, CN;Cooper, C
流行病学研究表明，婴儿时期的体重与日后患骨质疏松症的风险之间存在关联。这在多大程度上反映了出生前或出生后第一年环境对骨骼生长和新陈代谢的影响仍不确定。因此，我们在143名年龄在70-75岁的男性和女性的队列中研究了出生体重和成人身体成分(骨骼、瘦肉和脂肪质量)之间的关系，这些人出生在英国谢菲尔德，现在仍然住在那里。受试者接受了双能X射线骨密度仪的身体成分评估。新生儿的人体测量信息包括出生体重、出生长度、头部大小和腹围。在男性和女性中，出生体重与成人、全身、骨骼和瘦体重之间存在显著的正相关(P<；0.01)。这些都反映在出生体重与腰椎和股骨颈骨矿含量之间的显著相关性(P<；0.03)。出生体重和全身脂肪之间的相关性较弱，没有统计学意义。在调整了年龄、性别和成人身高后，出生体重与全身骨矿物质和瘦体重的相关性仍然具有统计学意义。在对吸烟、饮酒、饮食钙摄入量和缺乏体力活动进行调整后，这些因素仍然显著。这些数据与之前的观察一致，即婴儿期的人体测量与成年后的骨骼大小有关。出生时这些关系的存在进一步证明，骨骼和肌肉的生长可能是由宫内生活中的遗传和/或环境影响决定的。
Epidemiological studies suggest an association between weight in infancy and the risk of osteoporosis in later life. The extent to which this reflects environmental influences on skeletal growth and metabolism before birth or during the first year of postnatal life remains uncertain. We therefore examined the association between birth weight and adult body composition (bone, lean, and fat mass) in a cohort of 143 men and women, aged 70-75 yr, who were born in Sheffield, UK, and still lived there. The subjects underwent assessment of body composition by dual energy x-ray absorptiometry. Neonatal anthropometric information included birth weight, birth length, head size, and abdominal circumference. There were significant (P < 0.01) positive associations between birth weight and adult, whole body, bone, and lean mass among men and women. These were mirrored in significant (P < 0.03) associations between birth weight and bone mineral content at the lumbar spine and femoral neck. Associations between birth weight and whole body fat were weaker and not statistically significant. The associations of birth weight with whole body bone mineral and lean mass remained statistically significant after adjustment for age, sex, and adult height. They also remained significant after adjustment for cigarette smoking, alcohol consumption, dietary calcium intake, and physical inactivity. These data are in accord with previous observations that anthropometric measures in infancy are associated with skeletal size in adulthood. The presence of these relationships at birth adds to the evidence that bone and muscle growth may be programmed by genetic and/or environmental influences during intrauterine life.