Hepatic radiofrequency ablation at low frequencies preferentially heats tumour tissue.
Hepatic radiofrequency ablation at low frequencies preferentially heats tumour tissue.
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DOI：
10.1080/02656730601024727
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发表时间：
2006-11-01
期刊：
影响因子：
--
通讯作者：
Wood, Bradford J
中科院分区：
文献类型：
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作者：
Haemmerich, Dieter;Wood, Bradford J
目的：放射性消融是临床上接受的肝癌治疗方式。肝脏中正常组织和癌组织之间的介电特性存在显著差异，这在低于100 kHz的频率下特别明显。本研究进行了计算机模拟，以确定是否射频（RF）消融在较低的频率比目前采用的（450-500 kHz）可以利用这种差异，优先存款能量内tumor.MATERIALS和METHODS：有限元法计算机模型创建一个冷却针电极和多齿RF电极插入到一个2厘米直径的肿瘤。模拟射频消融，并确定电流密度以及组织温度分布。在体内的数据被用于在模型中的正常和癌组织的电导率，以模拟在肝脏中的射频消融在目前使用的频率为500 kHz和在10 kHz.RESULTS：在500 kHz的射频电流密度和最终组织之间的温度差异不大正常和癌组织。由于在10 kHz下电导率的差异更明显，因此癌组织优先在该频率下加热。取决于功率控制算法，这导致在10 kHz的肿瘤内温度较高或肿瘤外温度较低相比，500 KHz.CONCLUSION：射频消融在较低的频率比目前使用的可能会优先加热肿瘤和保存正常组织。可以设计用于选择性肿瘤破坏的靶向装置以利用该原理。
PURPOSE: Radiofrequency ablation is a clinically accepted treatment modality for liver cancer. There are significant differences in dielectric properties between normal and cancer tissue in the liver, which are particularly pronounced at frequencies below 100 kHz. This study performed computer simulations to determine whether radiofrequency (RF) ablation at lower frequencies than currently employed (450-500 kHz) can take advantage of this difference to preferentially deposit energy within the tumour.MATERIALS AND METHODS: Finite Element Method computer models were created for a cooled needle electrode and a multi-tine RF electrode inserted into a 2 cm diameter tumour. RF ablation was simulated and current density as well as tissue temperature distribution determined. In vivo data were used on electrical conductivity of normal and cancer tissue in the models to simulate RF ablation in liver at the currently used frequency of 500 kHz and at 10 kHz.RESULTS: At 500 kHz there was little difference in RF current density and final tissue temperature between normal and cancer tissue. Due to the more pronounced differences in electrical conductivity at 10 kHz, cancer tissue was heated preferentially at this frequency. Depending on power control algorithm, this resulted in either higher intra-tumour temperatures or lower temperatures outside the tumour at 10 kHz compared to 500 kHz.CONCLUSION: Radiofrequency ablation at lower frequencies than currently used may preferentially heat the tumour and preserve normal tissue. A targeted device for selective tumour destruction may be designed to make use of this principle.