Modeling pancreatic cancer with organoids.
Modeling pancreatic cancer with organoids.
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DOI：
10.1016/j.trecan.2016.03.004
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发表时间：
2016-04
期刊：
影响因子：
18.4
通讯作者：
Tuveson DA
中科院分区：
文献类型：
--
作者：
Baker LA;Tiriac H;Clevers H;Tuveson DA
胰腺导管腺癌（PDA）是一种高度致命的恶性肿瘤，迫切需要新的治疗和诊断方法。为了发现这些突破，研究人员需要能够准确模拟PDA发育和生物学的系统。虽然细胞系、基因工程小鼠模型和异种移植物都带来了有价值的临床见解，但器官型培养模型已成为概括PDA复杂三维组织的易处理系统。最近，已经报道了使用类器官建模PDA的多种方法。本文旨在总结这些类器官的方法在其他PDA模型的背景下。虽然每个模型系统都有独特的优点和缺点，但最终，类器官对个性化医疗方法的发展具有特殊的前景。
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new treatment and diagnostic approaches are urgently needed. In order for such breakthroughs to be discovered, researchers require systems that accurately model the development and biology of PDA. While cell lines, genetically engineered murine models, and xenografts have all led to valuable clinical insights, organotypic culture models have emerged as tractable systems to recapitulate the complex three-dimensional organization of PDA. Recently, multiple methods for modeling PDA using organoids have been reported. This review aims to summarize these organoid methods in the context of other PDA models. While each model system has unique benefits and drawbacks, ultimately, organoids hold special promise for the development of personalized medicine approaches.