Oxidant stress in asthma
Oxidant stress in asthma
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DOI：
10.1136/thorax.55.suppl_2.s51
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发表时间：
2000-10-01
期刊：
影响因子：
10
通讯作者：
Dworski, R
中科院分区：
文献类型：
--
作者：
Dworski, R
哮喘是一种病因不明的呼吸道慢性炎症性疾病。在严重哮喘中，气道素质是深刻的，因此是明显的。然而，最近有证据表明，即使在轻度疾病受试者的气道中也存在特定的炎症异常。由于炎症通常与活性氧（ROS）的产生增加有关，并且哮喘气道中的生化环境有利于自由基介导的反应，因此有理由认为氧化应激在哮喘中可能具有重要的机制。
Asthma is a chronic inflammatory disease of the respiratory tract of unknown aetiology. In severe asthma airway diathesis is profound, and thus apparent. Recently, however, evidence has indicated that specific inflammatory abnormalities exist even in the airways of subjects with mild disease. As inflammation is often associated with an increased generation of reactive oxygen species (ROS), and the biochemical environment in the asthmatic airways is favourable for free radical mediated reactions, it is rational to surmise that an oxidant stress could be mechanistically important in asthma.