Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet
Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet
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DOI：
10.1152/ajpregu.00549.2009
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发表时间：
2010-10-01
影响因子：
2.8
通讯作者：
Bessesen, Daniel H.
中科院分区：
文献类型：
--
作者：
Jackman, Matthew R.;MacLean, Paul S.;Bessesen, Daniel H.
Jackman先生，MacLean PS，Bessesen DH。高脂饮食前后肥胖倾向大鼠和肥胖抵抗大鼠的能量消耗。Am J Physiol Regul Integr Comp Physiol 299：R1097-R1105,2010.2010年8月4日首次出版；DOI：10.1152/ajpregu.00549.2009。虽然大多数大鼠在高脂饮食下体重增加，但一些品系抵抗高脂饮食诱导的体重增加。为了保持体重，肥胖抵抗(OR)大鼠必须吃得比肥胖倾向(OP)大鼠少，或者必须增加总能量消耗(TEE)。为了确定TEE的变化是否易于或防止体重增加，测量了食用低脂饮食(LFD)的雄性和雌性OP和OR大鼠以及改用HFD后5天的能量消耗、能量摄入量和体重增加。服药5天后，OP大鼠的体重增加(雄性：42.8+/-6.9g，雌性：25.5+/-3.0g)显著高于OR大鼠(雄性：24.0+/-7.5g，雌性：13.7+/-1.4g)。雄性和雌性大鼠在过渡到HFD时都显著增加了能量摄入量，而TEE在所有组中都略有增加。与雌性OP大鼠相比，雌性OR大鼠在HFD上的TEE显著增加。这是由于静息和非静息能量消耗的增加。相比之下，HFD对男性的影响很小。TEE也在摄入一对低密度脂蛋白热量的高脂饮食的雌性大鼠身上测量。成对喂养的雌性OR大鼠的TEE增加明显低于HFD临时条件下的TEE增加。雌性大鼠的体力活动也被测量。没有证据表明，体力活动的增加是服用HFD的雌性或大鼠TEE增加的原因。这些结果表明，雌性OR大鼠对HFD诱导的体重增加的抵抗力可能部分是由于TEE的增加和对脂质作为能量来源的更多依赖。TEE的变化似乎是由过量摄入高脂蛋白引起的，而不仅仅是饮食结构。
Jackman MR, MacLean PS, Bessesen DH. Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet. Am J Physiol Regul Integr Comp Physiol 299: R1097-R1105, 2010. First published August 4, 2010; doi:10.1152/ajpregu.00549.2009.-While most rats gain weight when placed on a high-fat diet (HFD), some strains resist HFD-induced weight gain. To maintain weight, obesity-resistant (OR) rats must either eat less than obesity-prone (OP) rats or increase total energy expenditure (TEE). To determine if changes in TEE predispose to or protect from weight gain, energy expenditure, energy intake, and weight gain were measured in male and female OP and OR rats consuming a low-fat diet (LFD) and for 5 days after switching to a HFD. After 5 days on a HFD, OP rats gained significantly more weight (male: 42.8 +/- 6.9 g, female: 25.5 +/- 3.0 g) than their OR counterparts (male: 24.0 +/- 7.5 g, female: 13.7 +/- 1.4 g). Both male and female rats significantly increased their energy intake when transitioned to the HFD, and TEE increased modestly in all groups. Compared with female OP rats, female OR rats had a significantly greater increase in TEE on the HFD. This was due to an increase in both resting and nonresting energy expenditure. In contrast, the effect of the HFD in males was minor. TEE was also measured in female rats consuming a HFD, pair fed to LFD calories. The increase in TEE of pair-fed female OR rats was substantially less than what was seen in the HFD ad libitum condition. Physical activity was also measured in female rats. There was no evidence that increases in physical activity were the cause of the increased TEE seen in female OR rats consuming a HFD. These results suggest that resistance to HFD-induced weight gain in female OR rats may be due in part to an increase in TEE and a greater reliance on lipid as an energy source. Changes in TEE appear to be triggered by overconsumption of the HFD and not simply the diet composition.