Activation of the amygdala and interior cingulate during nonconscious processing of sad versus happy faces
Activation of the amygdala and interior cingulate during nonconscious processing of sad versus happy faces
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DOI：
10.1016/j.neuroimage.2003.12.033
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发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Yurgelun-Todd, DA
中科院分区：
文献类型：
--
作者：
Killgore, WDS;Yurgelun-Todd, DA
以前的功能神经成像研究表明，杏仁核对低于有意识视觉感知阈值的恐惧面孔做出反应时会激活。使用与先前研究类似的后向掩蔽程序，我们使用功能磁共振成像(FMRI)来研究悲伤和快乐面部情绪的预注意呈现期间的杏仁核和前扣带回。12名健康的成年女性接受了血氧水平依赖(BOLD)功能磁共振成像，同时观看悲伤和快乐的面孔，每个面孔呈现20英寸，并立即被中性面孔遮盖100毫秒。掩饰的快乐面孔与双侧前扣带回和杏仁核的激活显著相关，而掩饰的悲伤只在左侧扣带回前区产生有限的激活。在一个直接的对比中，与相同面孔的悲伤面孔相比，蒙面的快乐面孔在前扣带回和杏仁核产生了显著更大的激活。联合分析表明，无论情绪价态如何，掩蔽的情感知觉与左侧杏仁核和左侧前扣带回内更大的激活有关。研究结果表明，杏仁核和前扣带回是网络的重要组成部分，该网络涉及检测和辨别低于正常有意识视觉知觉阈值的情感信息。(C)2004 Elsevier Inc.保留所有权利。
Previous functional neuroimaging studies have demonstrated that the amygdala activates in response to fearful faces presented below the threshold of conscious visual perception. Using a backward masking procedure similar to that of previous studies, we used functional magnetic resonance imaging (fMRI) to study the amygdala and anterior cingulate gyrus during preattentive presentations of sad and happy facial affect. Twelve healthy adult females underwent blood oxygen level dependent (BOLD) fMRI while viewing sad and happy faces, each presented for 20 ins and "masked" immediately by a neutral face for 100 ms. Masked happy faces were associated with significant bilateral activation within the anterior cingulate gyrus and amygdala, whereas masked sadness yielded only limited activation within the left anterior cingulate gyros. In a direct comparison, masked happy faces yielded significantly greater activation in the anterior cingulate and amygdala relative to identically masked sad faces. Conjunction analysis showed that masked affect perception, regardless of emotional valence, was associated with greater activation within the left amygdala and left anterior cingulate. Findings suggest that the amygdala and anterior cingulate are important components of a network involved in detecting and discriminating affective information presented below the normal threshold of conscious visual perception. (C) 2004 Elsevier Inc. All rights reserved.