Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma.
Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma.
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治疗前中性粒细胞与淋巴细胞的比率与中性粒细胞和 T 细胞浸润相关，可预测胶质母细胞瘤患者的临床结果
DOI：
10.1186/s12885-015-1629-7
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发表时间：
2015-09-04
期刊：
影响因子：
3.8
通讯作者：
Wu A
中科院分区：
文献类型：
--
作者：
Han S;Liu Y;Li Q;Li Z;Hou H;Wu A
背景全身炎症标志物与多种癌症患者的生存率相关。比较了嗜血小板淋巴细胞比率（NLR）和血小板淋巴细胞比率（PLR）在胶质母细胞瘤患者中的预后价值。方法对152例胶质母细胞瘤患者的临床资料进行回顾性分析。从电子病历中获得临床信息。Kaplan-Meier分析和考克斯比例风险模型用于检查这些胶质母细胞瘤患者中治疗前NLR和PLR的生存函数。神经元和CD 3 + T细胞浸润进行了评估，免疫组化染色的组织微阵列核心从glioblastomas.ResultsPre-treatment NLR水平显着相关的总生存期（OS）在胶质母细胞瘤患者（多变量风险比=1.050; 95%置信区间，1.003-1.100;P= 0.037）。尽管NLR与PLR之间存在相关性（R= 0.509，P < 0.001），但NLR作为预后因素的价值上级于PLR。治疗前NLR（≥4 vs < 4）与肿瘤内高中性粒细胞浸润和低CD 3 + T细胞浸润显著相关，并预测OS（平均10.6 vs 17.9个月，P< 0.001）。我们的研究结果表明外周血NLR水平升高与肿瘤中性粒细胞浸润增加/CD 3 + T细胞浸润减少之间存在相关性。
BackgroundMarkers of systemic inflammation are correlated with patient survival in various cancers. The prognostic value of neutrophil-to-lymphocyte ratio (NLR) was compared with that of platelet-to-lymphocyte ratio (PLR) in patients with glioblastoma. The association of NLR with neutrophil and T- cell infiltration was also explored.MethodsA total of 152 patients with glioblastoma were retrospectively analyzed. Clinical information was obtained from electronic medical records. Kaplan-Meier analysis and the Cox proportional hazards models were used to examine the survival function of pre-treatment NLR and PLR in these glioblastoma patients. Neutrophil and CD3+T-cell infiltration was assessed by immunohistochemical staining of tissue microarray cores from glioblastomas.ResultsPre-treatment NLR levels were significantly correlated with overall survival (OS) in glioblastoma patients (multivariate hazard ratio =1.050; 95 % confidence interval, 1.003–1.100;P= 0.037). Despite the correlation between NLR and PLR (R= 0.509,P< 0.001), NLR was superior to PLR as a prognostic factor. High pre-treatment NLR (≥4 versus < 4) was significantly associated with high neutrophil infiltration and low CD3+T-cell infiltration into tumors, and predicted poor OS (mean, 10.6vs.17.9 months,P< 0.001).ConclusionsPre-treatment NLR is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor. Our results demonstrate a correlation between elevated peripheral blood NLR levels and increased tumor neutrophil infiltration/decreased CD3+T-cell infiltration.