Effect of chronic kidney disease on the healing of titanium implants.
Effect of chronic kidney disease on the healing of titanium implants.
复制标题
DOI：
10.1016/j.bone.2013.07.014
复制
发表时间：
2013-10
期刊：
影响因子：
4.1
通讯作者：
Lanske, Beate
中科院分区：
文献类型：
--
作者：
Zou, Huawei;Zhao, Xuefeng;Sun, Ningyuan;Zhang, Shiwen;Sato, Tadatoshi;Yu, Haiyang;Chen, Qianming;Weber, Hans-Peter;Dard, Michel;Quan Yuan;Lanske, Beate
关键词：
慢性肾脏病（CKD）已成为全球性的公共卫生问题。然而，其对牙种植体骨整合的影响在很大程度上是未知的。本研究的目的是调查CKD是否会损害钛种植体的骨结合质量。5/6肾切除造成小鼠尿毒症，血清BUN、FGF 23、PTH和ALP水平显著升高。对于体外测试，获得骨髓间充质干细胞（BMMSC）并在钛盘上培养。通过qPCR定量，成骨标志物基因（包括Osx、Col-1、Ocn和Opn）的表达无显著差异。此外，茜素红S染色显示相当的矿化结节形成。对插入CKD小鼠股骨中的实验植入物的组织形态计量学分析显示，在2周愈合时BIC比率有下降的趋势。通过推入法测量的骨-种植体结合强度在2周时显著低于CKD组，尽管在4周时达到了相当的水平。这些结果表明CKD仅在早期阶段对钛种植体的骨结合产生负面影响。
Chronic kidney disease (CKD) has become a worldwide public health problem. However, its effect on osseointegration of dental implants is largely unknown. The aim of this study is to investigate whether CKD impairs the quality of the osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in mice, and serum levels of BUN, FGF23, PTH and ALP were significantly increased. For in vitro tests, bone marrow mesenchymal stem cells (BMMSCs) were obtained and cultured on titanium discs. There was no significant difference in term of expression of osteogenic marker genes including Osx, Col-1, Ocn, and Opn, as quantified by qPCR. Moreover, Alizarin Red S staining showed comparable mineralized nodules formation. Histomorphometrical analysis of experimental implants inserted in the femurs of CKD mice revealed a trend of decreased BIC ratio at 2-week healing. The strength of bone-implant integration, as measured by a push-in method, was significantly lower for the CKD group at 2 weeks, although a comparable level was reached at 4 weeks. These results demonstrated that CKD only negatively affects the osseointegration of titanium implants at the early stage.
登录
查看更多内容
影响因子：
3.8
作者：
Cengiz, M. I.;Suemer, P.;Yavuz, U.
通讯作者：
Yavuz, U.
DOI：
10.1038/ki.2009.188
发表时间：
2009-08-01
期刊：
Kidney international. Supplement
影响因子：
--
作者：
通讯作者：
--
影响因子：
13.6
作者：
Hallan, Stein I.;Coresh, Josef;Holmen, Jostein
通讯作者：
Holmen, Jostein
影响因子：
6.1
作者：
Borawski, Jacek;Wilczynska-Borawska, Magdalena;Mysliwiec, Michal
通讯作者：
Mysliwiec, Michal
影响因子：
4.1
作者：
Yoshiko, Yuji;Wang, Hua;Maeda, Norihiko
通讯作者：
Maeda, Norihiko