DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
复制标题
DOI：
10.3390/app112210856
复制
发表时间：
2021-11-01
影响因子：
2.7
通讯作者：
Chow, James C. L.
中科院分区：
文献类型：
--
作者：
Huynh, Ngoc Han;Chow, James C. L.
重原子纳米粒子，例如金纳米粒子，被证明是放射治疗中有效的放射增敏剂，可以增强癌症治疗的剂量输送。这项研究通过改变纳米颗粒尺寸、质子束能量以及纳米颗粒与 DNA 之间的距离，研究了质子辐射中金纳米颗粒杀死癌细胞的有效性。当金纳米颗粒与 DNA 一起存在时，蒙特卡罗 (MC) 模拟（Geant4-DNA 代码）用于确定剂量增强比 (DER) 方面的剂量增强。根据模拟模型，改变纳米颗粒尺寸（半径= 15-50 nm）、金纳米颗粒与DNA之间的距离（30-130 nm）以及质子束能量（0.5-25 MeV），我们的结果表明，DER值随着金纳米颗粒与DNA之间距离的减小和质子束能量的减小而增大。最大 DER (1.83) 是使用半径为 25 nm 的金纳米颗粒实现的，该纳米颗粒由 0.5 MeV 质子束照射并距离 DNA 30 nm。
Heavy atom nanoparticles, such as gold nanoparticles, are proven effective radiosensitizers in radiotherapy to enhance the dose delivery for cancer treatment. This study investigated the effectiveness of cancer cell killing, involving gold nanoparticle in proton radiation, by changing the nanoparticle size, proton beam energy, and distance between the nanoparticle and DNA. Monte Carlo (MC) simulation (Geant4-DNA code) was used to determine the dose enhancement in terms of dose enhancement ratio (DER), when a gold nanoparticle is present with the DNA. With varying nanoparticle size (radius = 15-50 nm), distance between the gold nanoparticle and DNA (30-130 nm), as well as proton beam energy (0.5-25 MeV) based on the simulation model, our results showed that the DER value increases with a decrease of distance between the gold nanoparticle and DNA and a decrease of proton beam energy. The maximum DER (1.83) is achieved with a 25 nm-radius gold nanoparticle, irradiated by a 0.5 MeV proton beam and 30 nm away from the DNA.