Early Treatment and HIV-1 Reservoirs: A Stitch in Time?
Early Treatment and HIV-1 Reservoirs: A Stitch in Time?
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DOI：
10.1093/infdis/jit307
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发表时间：
2013-10-15
影响因子：
6.4
通讯作者：
Gandhi, Rajesh T.
中科院分区：
文献类型：
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作者：
Henrich, Timothy J.;Gandhi, Rajesh T.
最近几项备受瞩目的研究强调了在急性人类免疫缺陷病毒1型（HIV-1）感染期间开始抗逆转录病毒治疗（ART）对病毒储库和持续性的潜在影响。在今年的“逆转录病毒和艾滋病感染会议”[1]上发表的令人兴奋的观察结果表明，密西西比一名感染母亲在出生后数小时内开始接受抗逆转录病毒治疗的儿童，立即治疗可以防止HIV-1在婴儿体内建立立足点，导致停止抗逆转录病毒治疗后病毒反弹的缺乏。另外两项研究表明，在急性HIV-1感染的成人中开始早期ART可能会限制关键病毒库的接种，包括在特定类型的记忆性CD 4 + T细胞中发现的那些[2-4]。虽然这些挑衅性报告中的观察结果的长期意义尚不清楚，但它们已经扩展了HIV-1治疗策略和持久性研究领域。在这个问题上的
Several recent high-profile studies have highlighted the potential impact of antiretroviral therapy (ART) initiation during acute human immunodeficiency virus type 1 (HIV-1) infection on viral reservoirs and persistence. Exciting observations presented at this year’s “Conference on Retroviruses and Opportunistic Infections”[1] on a child in Mississippi that started ART within hours of birth to an infected mother suggested that immediate treatment prevented HIV-1 from establishing a foothold in the infant, leading to lack of viral rebound after ART cessation. Two additional studies suggested that initiating early ART in adults with acute HIV-1 infection might limit seeding of key viral reservoirs, including those found in specific types of memory CD4+ T cells [2–4]. Although the long-term significance of the observations in these provocative reports is not yet known, they have invigorated the field of HIV-1 curative strategies and persistence research. In this issue of The