Sympathetic nerve activity and renal responses during continuous negative-pressure breathing in humans.
Sympathetic nerve activity and renal responses during continuous negative-pressure breathing in humans.
复制标题
人类持续负压呼吸期间的交感神经活动和肾脏反应。
DOI：
10.1152/ajpregu.1991.261.2.r276
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Shiraki,K
中科院分区：
文献类型：
--
作者：
Tanaka,H;Sagawa,S;Miki,K;Tajima,F;Freund,BJ;Claybaugh,JR;Shiraki,K
心肺感受器的牵张刺激由于肾交感神经活动的抑制而导致犬的利尿和尿钠排泄。在本实验中，拉伸刺激在人类中给予的手段，连续负压呼吸（CNPB），和肌肉交感神经活动（MSNA），肾反应，和激素进行了测量，以检查是否MSNA反应CNPB期间与通常的心肺感受器的拉伸刺激的肾和激素的反应。9名健康男性进行CNPB在-11毫米汞柱为60分钟。在腓肌神经束MSNA连续测量之前（前CNPB），期间，CNPB后（后CNPB）。CNPB期间观察到MSNA逐步持续降低（P <0.05）（爆发频率为CNPB前水平的30 +/- 6%，总活性为CNPB前水平的37 +/- 4%），CNPB后恢复至CNPB前水平。CNPB期间尿排泄增加58 +/- 18%（P <0.05），由于Na排泄显著增加（P <0.05）和恒定的游离水清除率，利尿本质上完全是渗透压。血浆去甲肾上腺素水平在CNPB过程中显著下降（P <0.05），CNPB后仍保持下降趋势（P <0.05）。CNPB期间观察到血浆心钠素增加两倍（P <0.05），血浆肾素活性降低35 ± 9%（P <0.05），而血浆醛固酮和精氨酸加压素无变化。（250字处删节）
A stretch stimulus of the cardiopulmonary receptors results in a diuresis and natriuresis in dogs due to a suppression of renal sympathetic nerve activity. In the present experiment, the stretch stimulus in humans was given by means of continuous negative-pressure breathing (CNPB), and muscle sympathetic nerve activity (MSNA), renal responses, and hormones were measured to examine whether MSNA response during CNPB correlated with the usual renal and hormonal responses for stretch stimulus of the cardiopulmonary receptors. Nine healthy males were subjected to CNPB at -11 mmHg for 60 min. MSNA in the peroneal muscle nerve fascicles was measured continuously before (pre-CNPB), during, and after CNPB (post-CNPB). A step and sustained decrease (P less than 0.05) in MSNA (30 +/- 6% for burst frequency and 37 +/- 4% for total activity from pre-CNPB level) was observed during CNPB and it returned to pre-CNPB level at post-CNPB. Urinary excretion increased by 58 +/- 18% (P less than 0.05) during CNPB, and the diuresis was entirely osmolal in nature because of a significant increase (P less than 0.05) in Na excretion and a constant free-water clearance. The plasma level of norepinephrine decreased significantly (P less than 0.05) during CNPB and remained decreased (P less than 0.05) at post-CNPB. A twofold increase (P less than 0.05) in plasma atrial natriuretic peptide and a 35 +/- 9% reduction (P less than 0.05) in plasma renin activity were observed during CNPB, whereas no change was observed in plasma aldosterone and arginine vasopressin.(ABSTRACT TRUNCATED AT 250 WORDS)