Microfluidics to Mimic Blood Flow in Health and Disease
Microfluidics to Mimic Blood Flow in Health and Disease
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DOI：
10.1146/annurev-fluid-010816-060246
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发表时间：
2018-01
影响因子：
27.7
通讯作者：
B. Sebastian;P. Dittrich
中科院分区：
文献类型：
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作者：
B. Sebastian;P. Dittrich
纵观历史，毛细血管系统帮助建立了血液流动的基本规律及其非牛顿性质。20世纪90年代微流体技术的出现推动了高度集成的芯片实验室平台的发展，这些平台可以高度精确地复制血管系统的尺寸、机械特性和生物复杂性。应用包括以无与伦比的灵敏度检测红细胞、白细胞和血小板的病理变化，以及评估药物治疗的疗效。最近的努力旨在开发基于微流体的测试，可用于临床环境或更复杂的疾病（如血栓形成）的复制。这些微流控疾病模型能够研究疾病的发生和进展，以及识别关键参与者和风险因素，从而导致一系列临床相关发现。
Throughout history, capillary systems have aided the establishment of the fundamental laws of blood flow and its non-Newtonian properties. The advent of microfluidics technology in the 1990s propelled the development of highly integrated lab-on-a-chip platforms that allow highly accurate replication of vascular systems' dimensions, mechanical properties, and biological complexity. Applications include the detection of pathological changes to red blood cells, white blood cells, and platelets at unparalleled sensitivity and the efficacy assessment of drug treatment. Recent efforts have aimed at the development of microfluidics-based tests usable in a clinial environment or the replication of more complex diseases such as thrombosis. These microfluidic disease models enable the study of onset and progression of disease as well as the identification of key players and risk factors, which have led to a spectrum of clinically relevant findings.