RISK OF RESPIRATORY SYNCYTIAL VIRUS-INFECTION FOR INFANTS FROM LOW-INCOME FAMILIES IN RELATIONSHIP TO AGE, SEX, ETHNIC-GROUP, AND MATERNAL ANTIBODY LEVEL
RISK OF RESPIRATORY SYNCYTIAL VIRUS-INFECTION FOR INFANTS FROM LOW-INCOME FAMILIES IN RELATIONSHIP TO AGE, SEX, ETHNIC-GROUP, AND MATERNAL ANTIBODY LEVEL
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DOI：
10.1016/s0022-3476(81)80829-3
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发表时间：
1981-01-01
影响因子：
5.1
通讯作者：
FRANK, AL
中科院分区：
文献类型：
--
作者：
GLEZEN, WP;PAREDES, A;FRANK, AL
出生第一年因呼吸道合胞病毒 [RSV] 感染住院的风险为 .apprx。 1975 年至 1979 年间，美国德克萨斯州休斯顿低收入家庭每年有 5/1000 的婴儿活产。风险各不相同，具体取决于特定季节流行病的强度、婴儿的出生月份以及出生时被动获得的母体抗体的水平。超过 80% 的住院儿童年龄< 6 个月。年龄；因此，大多数人是在六个月内出生的。 RSV 活性峰值之前。 6 个月前经培养证实感染的 68 名婴儿的脐带血清中的中和抗体滴度。年龄显着低于随机抽取的 575 名同期出生婴儿的脐带样本。出生时的抗体水平与感染时的年龄直接相关。患有较严重疾病的婴儿在疾病发作前收集的血清中的抗体水平低于患有较轻疾病的婴儿。因此，尽管婴儿早期针对 RSV 感染的保护作用与母体抗体水平相关，但尚不清楚这种保护作用是由被动获得的抗体直接介导的还是由某些其他机制介导的。
The risk for hospitalization with respiratory syncytial virus [RSV] infection during the 1st yr of life was .apprx. 5/1000 live births per yr for infants born to low-income families in Houston, Texas, USA, from 1975-1979. The risk varied, depending on the intensity of the epidemic for a given season, the month of birth of the infant and the level of passively acquired maternal antibody at the time of birth. Over 80% of the children hospitalized were < 6 mo. of age; thus, most were born during the 6 mo. preceding the peak of RSV activity. The neutralizing antibody titers in cord sera of 68 infants with culture-proven infections before 6 mo. of age were significantly lower than those of 575 randomly selected cord samples of infants born during the same period. The level of antibody at the time of birth was directly correlated with age at the time of infection. Infants with more severe illnesses had lower levels of antibody in serum collected near onset of illness than did infants with milder illnesses. Thus, although protection against RSV infection in early infancy is correlated with the level of maternal antibody, it is not known if this protection is mediated directly by the passively acquired antibody or by some other mechanism.