Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization
Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization
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DOI：
10.1021/la048347t
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发表时间：
2004-11-23
期刊：
影响因子：
3.9
通讯作者：
Jérôme, C
中科院分区：
文献类型：
--
作者：
Ignatova, M;Voccia, S;Jérôme, C
新型共聚物刷是通过两步“接枝”方法合成的，该方法包括将聚(2-苯基-2-(2,2,6,6-四甲基-哌啶-1-基氧基)-丙烯酸乙酯)电接枝到不锈钢上，然后从电接枝的聚丙烯酸酯链引发2-(二甲氨基乙基)丙烯酸酯和苯乙烯或丙烯酸正丁酯的硝基氧介导的自由基聚合。接枝共聚物被季铵化以赋予其抗菌性能。剥离测试证实接枝共聚物对不锈钢基材具有很强的附着力。石英晶体微天平实验证明，与非离子对应物相比，亲水性季铵化膜上的纤维蛋白原粘附力较低。这种季铵化共聚物对革兰氏阳性菌金黄色葡萄球菌和革兰氏阴性菌大肠杆菌表现出显着的抗菌活性。
Novel copolymer brushes have been synthesized by a two-step "grafting from" method that consists of the electrografting of poly(2-phenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethylacrylate) onto stainless steel, followed by the nitroxide-mediated radical polymerization of 2-(dimethylamino ethyl)acrylate and styrene or n-butyl acrylate, initiated from the electrografted polyacrylate chains. The grafted copolymers were quaternized in order to endow them with antibacterial properties. Peeling tests have confirmed the strong adhesion of the grafted copolymer onto the stainless steel substrate. Quartz crystal microbalance experiments have proven that fibrinogen adhesion is lower on the hydrophilic quaternized films compared to the nonionic counterpart. Such quaternized copolymers exhibit significant antibacterial activity against the Gram-positive bacteria S. aureus and the Gram-negative bacteria E. coli.