Influence of Race on Microsatellite Instability and CD8+ T Cell Infiltration in Colon Cancer
Influence of Race on Microsatellite Instability and CD8+ T Cell Infiltration in Colon Cancer
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DOI：
10.1371/journal.pone.0100461
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发表时间：
2014-06-23
期刊：
影响因子：
3.7
通讯作者：
McGuire, Kathleen L.
中科院分区：
文献类型：
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作者：
Carethers, John M.;Murali, Bhavya;McGuire, Kathleen L.
非裔美国人结直肠癌患者的死亡率高于白人患者。生物学可能发挥部分作用，先前的研究表明，非裔美国人癌症中微卫星不稳定性（MSI）的患病率较高，尽管MSI癌症患者的生存率高于非MSI癌症患者，与非裔美国人患者观察到的结果相反。结肠癌的CD 8（+）T细胞浸润与MSI肿瘤呈正相关，也与预后改善有关。在此，我们利用了一个503人，以人群为基础的结肠癌队列，包括45%的非洲裔美国人，以确定，在盲法条件下，从所有流行病学数据，MSI和相关的CD 8（+）T细胞浸润的癌症的患病率。在白人癌症中，14%为MSI，而非裔美国人癌症的MSI为7%（P = 0.009）。在临床上，不同种族之间的MSI癌症是相似的;在微卫星稳定的癌症中，非裔美国人患者更年轻，女性，并且患有近端癌症。MSI组CD 8 + T细胞明显高于正常对照组（88.0vs30.4/hpf，P
African American patients with colorectal cancer show higher mortality than their Caucasian counterparts. Biology might play a partial role, and prior studies suggest a higher prevalence for microsatellite instability (MSI) among cancers from African Americans, albeit patients with MSI cancers have improved survival over patients with non-MSI cancers, counter to the outcome observed for African American patients. CD8(+) T cell infiltration of colon cancer is postively correlated with MSI tumors, and is also related to improved outcome. Here, we utilized a 503-person, population-based colon cancer cohort comprising 45% African Americans to determine, under blinded conditions from all epidemiological data, the prevalence of MSI and associated CD8(+) T cell infiltration within the cancers. Among Caucasian cancers, 14% were MSI, whereas African American cancers demonstrated 7% MSI (P = 0.009). Clinically, MSI cancers between races were similar; among microsatellite stable cancers, African American patients were younger, female, and with proximal cancers. CD8(+) T cells were higher in MSI cancers (88.0 vs 30.4/hpf, P