Microwave-Assisted Multicomponent Reactions in the Heterocyclic Chemistry
Microwave-Assisted Multicomponent Reactions in the Heterocyclic Chemistry
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DOI：
10.2174/138527210790231892
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发表时间：
2010-02-01
影响因子：
2.6
通讯作者：
Tu, Shu-Jiang
中科院分区：
文献类型：
--
作者：
Jiang, Bo;Shi, Feng;Tu, Shu-Jiang
新兴的多组分反应（MCR）与微波（MW）辅助化学技术的结合使用，大大减少了几种有机合成和化学转化中的化学废物和反应时间。MW辅助MCR提供了快速有效的程序，用于将许多结构多样性点引入以简单方式在单个合成步骤中制备的杂环化合物中。本文综述了分子筛辅助的MCRs在构建五元、六元和七元杂环骨架以及双环体系方面的最新进展。简单的和稠合的杂环目标的生成方法进行了描述，特别强调引入结构的多样性和复杂性。在许多情况下，MW辅助的MCR在选择性、化学产率和纯度方面提供了相当大的改进，并且构成了获得各种杂环基序的非常简单且极其快速的方法。
The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. The MW-assisted MCRs offer rapid and efficient procedures for the introduction of many points of structural diversity into heterocyclic compounds prepared in a straightforward manner in a single synthetic step. The present review summarizes recent developments in MW-assisted MCRs for the construction of five-, six-, and seven-membered heterocyclic skeletons as well as dicyclic system. Methods for the generation of both simple and fused heterocyclic targets are described, with particular emphasis on the introduction of structural diversity and complexity. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitute a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.