CRYPTOSPORIDIOSIS
CRYPTOSPORIDIOSIS
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DOI：
10.1016/s0272-2712(18)30525-0
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发表时间：
1991-12-01
影响因子：
1.7
通讯作者：
GARCIA, LS
中科院分区：
文献类型：
--
作者：
CURRENT, WL;GARCIA, LS
1982年之前，人类隐孢子虫病的病例报告仅有8篇，关于隐孢子虫病的论文不到30篇。出现在生物医学文献中。当时，隐孢子虫病被认为是动物中的罕见感染，而人类中则很少是机会性感染。隐孢子虫属的概念。由于诊断技术的改进、生物医学界认识的提高以及众多实验室基础研究项目的发展，病原体在过去 8 年里发生了巨大的变化。目前，超过 1,000 种出版物（包括生物医学文献中的 400 多份病例报告）涉及隐孢子虫属。和隐孢子虫病。小隐孢子虫现在被认为是引起全世界人类腹泻疾病的三种最常见的肠道病原体之一，特别是在发展中国家。隐孢子虫病可能曾被包括在 25% 至 35% 的病因不明的腹泻疾病中。由于腹泻病的严重性和持续时间，并且由于尚未确定有效的治疗方法，隐孢子虫病是与艾滋病相关的最不祥的感染之一。小隐孢子虫作为肠道病原体的作用已得到充分证实。其作为肝胆和呼吸系统疾病病因的文献现已出现在文献中。我们目前对隐孢子虫属的自然史、流行病学、生物学和免疫学的了解。本文将总结隐孢子虫病的临床特征、致病性和治疗。
Before 1982, only eight case reports of human cryptosporidiosis and fewer than 30 papers on Cryptosporidium spp. appeared in the biomedical literature. At that time, cryptosporidiosis was thought to be an infrequent infection in animals and rarely an opportunistic infection in humans. The concept of Cryptosporidium spp. as pathogens has changed dramatically within the past 8 years because of improved diagnostic techniques, increased awareness within the biomedical community, and the development of basic research programs in numerous laboratories. Presently, greater than 1,000 publications including over 400 case reports in the biomedical literature address Cryptosporidium spp. and cryptosporidiosis. Cryptosporidium parvum is now thought to be one of the three most common enteropathogens causing diarrheal illness in humans worldwide, especially in developing countries. It is likely that cryptosporidiosis was previously included in the 25 to 35% of diarrheal illness with unknown etiology. Because of the severity and length of diarrheal illness and because no effective therapy has been identified, cryptosporidiosis is one of the most ominous infections associated with AIDS. The role of C. parvum as an enteropathogen is well established; documentation of its role as a cause of hepatobiliary and respiratory diseases is now appearing in the literature. Our present understanding of the natural history, epidemiology, biology, and immunology of Cryptosporidium spp. as well as the clinical features, pathogenicity, and treatment of cryptosporidiosis are reviewed here.