A Transient Elevated Irisin Blood Concentration in Response to Prolonged, Moderate Aerobic Exercise in Young Men and Women
A Transient Elevated Irisin Blood Concentration in Response to Prolonged, Moderate Aerobic Exercise in Young Men and Women
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DOI：
10.1055/s-0033-1355381
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发表时间：
2014-02-01
影响因子：
2.2
通讯作者：
Castracane, V. D.
中科院分区：
文献类型：
--
作者：
Kraemer, R. R.;Shockett, P.;Castracane, V. D.
Irisin是一种新发现的PGC-1α依赖性肌因子，最近被证明在短跑运动中循环增加。本研究检测了在月经周期的不同阶段，长期运动对年轻男性（n=7）和年轻女性（n=5）中鸢尾素浓度的影响。7名年轻男性完成了90分钟的跑步机运动，60%的VO 2 max和休息对照试验。五名女性在两个不同的试验中完成了相同的运动方案：在月经周期的卵泡早期和黄体中期。在运动前即刻、运动后54和90 min以及恢复后20 min（R20）采集血样并分析鸢尾素浓度。研究结果显示，在60%的VO 2 max下进行90分钟跑步机运动方案的54分钟，年轻男性的鸢尾素浓度显著增加20.4%，在月经周期的早期卵泡期和中期黄体期，年轻女性的鸢尾素浓度分别增加20.3%和24.6%。然而，通过90分钟的运动以及R20，鸢尾素浓度不再升高。月经周期的阶段并不影响年轻女性的反应。研究结果表明，长时间的有氧运动产生短暂的增加鸢尾素浓度在运动的第一个小时为两种性别，并建议这种形式的适度运动可能有助于改善脂肪代谢。
Irisin, a newly discovered, PGC-1α dependent myokine, has recently been shown to increase in circulation in response to sprint exercise. This study examined the effect of prolonged exercise on irisin concentrations in young men (n=7) as well as in young women (n=5) during different stages of the menstrual cycle. Seven young men completed 90 min of treadmill exercise at 60% of VO2max and a resting control trial. Five women completed the same exercise protocol in two different trials: during the early follicular phase and mid-luteal phase of the menstrual cycle. Blood samples were collected and analyzed for irisin concentrations immediately before exercise, at 54 and 90 min of exercise, and at 20 min of recovery (R20). Findings revealed that by 54 min of a 90 min treadmill exercise protocol at 60% of VO2max, irisin concentrations significantly increased 20.4% in young men and 20.3% as well as 24.6% in young women during the early follicular and mid-luteal phases of the menstrual cycle, respectively. However, by 90 min of exercise as well as R20, irisin concentrations were no longer elevated. Stage of the menstrual cycle did not affect responses in young women. Findings indicate that prolonged aerobic exercise produces a transient increase in irisin concentrations during the first hour of exercise for both genders and suggest that this form of moderate exercise may be helpful in improving fat metabolism.