Morbidity associated with MDMA (ecstasy) abuse: A survey of emergency department admissions
Morbidity associated with MDMA (ecstasy) abuse: A survey of emergency department admissions
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DOI：
10.1177/0960327110370984
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发表时间：
2011-04-01
影响因子：
2.8
通讯作者：
Peleg, Kobi
中科院分区：
文献类型：
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作者：
Halpern, Pinchas;Moskovich, Jenny;Peleg, Kobi
研究方法：我们进行了一项前瞻性、代表性样本的全国性研究，研究与3，4-亚甲二氧基甲基苯丙胺（MDMA;“摇头丸”）相关的发病率，这些发病率是根据5个具有地理代表性的急诊科（ED）的入院情况和毒物信息中心（PIC）的数据确定的。在7个月的时间内分析了MDMA相关的艾德入院情况，并审查了所有PIC电话的记录。结果：在研究期间，有52例（年龄15-44岁，32例男性）与迷魂药相关的艾德入院。大多数（68%）在晚上到艾德就诊，52%在周末，44%在俱乐部和聚会上服用药物。46%的患者服用1/2至3片摇头丸，29名患者（56%）以前服用过摇头丸。22例受试者（42%）报告使用多种药物。15例受试者（29%）需要住院治疗，其中6例（11%）需要入住重症监护室。最常见的临床表现是坐立不安、激动、定向力障碍、颤抖、高血压、头痛和意识丧失。较严重的并发症有高热、低钠血症、横纹肌溶解、脑水肿和昏迷。结论：摇头丸作为一种安全的聚会药物的形象是虚假的。这项研究的结果证实，这种药物具有真实的身体伤害和行为、心理和精神障碍的危险。
Methods: We conducted a prospective, representative-sample nationwide study on morbidity related to 3,4, methylenedioxymethamphetamine (MDMA; 'ecstasy') as determined from admissions to 5 geographically representative emergency departments (EDs) and from data from the poison information center (PIC). MDMA-related ED admissions were analyzed over a 7-month period and the records of all PIC calls were reviewed. Results: There were 52 (age 15-44 years, 32 males) ecstasy-related ED admissions during the study period. Most (68%) admissions presented to the ED at night, 52% on weekends and 44% consumed the drug at clubs and parties. Forty-six percent of the patients took between 1/2 to 3 tablets and 29 patients (56%) had taken ecstasy before. Twenty-two subjects (42%) reported poly-drug use. Fifteen subjects (29%) required hospitalization, six of them (11%) to the intensive care unit. The most common manifestations were restlessness, agitation, disorientation, shaking, high blood pressure, headache and loss of consciousness. More serious complications were hyperthermia, hyponatremia, rhabdomyolysis, brain edema and coma. Conclusion: The image of ecstasy as a safe party drug is spurious. The results of this study confirm that the drug bears real danger of physical harm and of behavioral, psychological and psychiatric disturbances.