Lesion characteristics and depressed mood in the stroke data bank study.
Lesion characteristics and depressed mood in the stroke data bank study.
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中风数据库研究中的病变特征和抑郁情绪。
DOI：
10.1176/jnp.8.2.153
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Price,TR
中科院分区：
文献类型：
--
作者：
Morris,PL;Robinson,RG;deCarvalho,ML;Albert,P;Wells,JC;Samuels,JF;Eden-Fetzer,D;Price,TR
本研究通过使用多中心国家卒中数据库的数据，检验了卒中后病变大小和位置与抑郁情绪之间的关系。对于首次脑梗死患者，通过CT扫描确定病变的位置和大小。研究的193名患者中有47名（24%）患有抑郁症。在完整的样本中，无论是病灶大小还是位置都与抑郁症无关。然而，在具有相似小尺寸病变的患者中（n= 124），左半球卒中患者的抑郁发生率高于右半球卒中患者（31% vs. 16%; P= 0.04）。在病变较大的患者中，脑水肿是常见的，可能掩盖了偏侧的结果。不同的生物胺神经递质的反应，左右半球的脑损伤可能是这种情绪不对称的基础。
This study examined the relationship between post-stroke lesion size and location and depressed mood by using data from the multicenter National Stroke Data Bank. For in patients with first-ever cerebral infarction, lesions were characterized by location and size from CT scans. Forty-seven (24%) of the 193 patients studied were depressed. In the complete sample, neither lesion size nor location was associated with depression. However, among patients with comparable small-sized lesions (n= 124), depression was more frequent among those with left hemisphere stroke than those with right hemisphere stroke (31% vs. 16%; P= 0.04). Among patients with larger lesions, brain edema was common and may have obscured lateralized findings. Different biogenic amine neurotransmitter responses to right and left hemisphere brain injury may underlie this mood asymmetry.