Recent Advances in Iminium-Salt-Catalysed Asymmetric Epoxidation
Recent Advances in Iminium-Salt-Catalysed Asymmetric Epoxidation
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DOI：
10.1002/ejoc.201600908
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发表时间：
2017-02-10
影响因子：
2.8
通讯作者：
Sellars, Philip B.
中科院分区：
文献类型：
--
作者：
Day, David P.;Sellars, Philip B.
环氧化物是存在于生物活性天然产物中的重要官能团，并作为形成更复杂分子结构的有用构件。虽然不对称环氧化方法已经知道了四十年，但近年来一直在推动使用有机催化剂进行转化。本文综述了亚胺盐作为有机催化剂在不对称环氧化反应中的应用。我们特别关注基于联萘和联苯体系的二氢异喹啉盐和亚胺盐在广泛的烯烃底物的不对称环氧化中的应用。
Epoxides are important functional groups that are present in bioactive natural products and serve as useful building blocks for the formation of more complex molecular architectures. While asymmetric epoxidation methods have been known for four decades, in recent years there has been a drive to carry out transformations using organocatalysts. In this review we will discuss the application of iminium salts as organocatalysts in asymmetric epoxidation reactions, which has received a lot of attention over the last decade. We pay particular attention to the use of dihydroisoquinolinium salts and iminium salts based on binaphthyl and biphenyl systems in the asymmetric epoxidation of a broad range of olefin substrates.