Functional correlates of vertical gaze palsy and other ocular motor deficits in PSP: An FDG-PET study
Functional correlates of vertical gaze palsy and other ocular motor deficits in PSP: An FDG-PET study
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DOI：
10.1016/j.parkreldis.2014.05.013
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发表时间：
2014-08-01
影响因子：
4.1
通讯作者：
Meyer, Philipp T.
中科院分区：
文献类型：
--
作者：
Amtage, Florian;Maurer, Christoph;Meyer, Philipp T.
目的：采用[F-18]氟脱氧葡萄糖（FDG-）PET确定进行性核上性麻痹（PSP）患者垂直凝视麻痹和其他眼运动缺陷的功能相关性。方法：26例PSP患者接受了垂直凝视结合FDG-PET扫描的临床检查，以评估局部脑葡萄糖代谢作为神经元活动的标志物。其中，18例PSP患者也进行了调查，以确定水平眼运动缺陷的电眼震描记术。统计参数映射分析进行相关区域神经元活动与眼运动functions.Results：在分类比较，向下凝视麻痹的患者表现出显着降低葡萄糖代谢的双边前扣带回和右舌回相比，那些没有向下凝视麻痹。水平扫视的最大速度与吻蚓部和舌回的葡萄糖代谢呈正相关;眼蚓部的区域代谢与视动反射的峰值速度相关。平滑追踪眼动幅度和校正性眼跳峰值速度分析显示，校正性眼跳与双侧顶叶下叶和额眼野下部的代谢呈正相关。所有平滑追踪模式均与V5葡萄糖代谢呈正相关。结论：PSP患者的眼运动功能与不同解剖部位的神经元活动相关。这些包括前扣带回（向下凝视麻痹）、小脑喙部（扫视）、眼动蚓部（视动反射）和下顶叶以及颞叶区域和额叶视野（平滑追踪）。这些发现提供了一个更深入的了解PSP相关的眼运动异常的病理生理。(C)2014爱思唯尔有限公司版权所有。
Objective: To determine the functional correlates of vertical gaze palsy and other ocular motor deficits in patients with progressive supranuclear palsy (PSP) using [F-18]fluorodeoxyglucose (FDG-)PET.Methods: Twenty-six patients with PSP underwent clinical examination of vertical gaze combined with FDG-PET scans to assess regional cerebral glucose metabolism as a marker of neuronal activity. Of these, eighteen PSP patients were also investigated by electrical nystagmography to determine horizontal ocular motor deficits. Statistical parametric mapping analyses were performed to correlate regional neuronal activity with ocular motor functions.Results: In categorical comparisons, patients with downward gaze palsy showed a significantly reduced glucose metabolism in bilateral anterior cingulate gyrus and right lingual gyrus compared to those without downward gaze palsy. Maximum velocity of horizontal saccades was positively correlated with glucose metabolism of the rostral vermis and lingual gyrus; regional metabolism of oculomotor vermis was associated with peak velocity of the optokinetic reflex. Analysis of smooth pursuit eye movement amplitude and peak velocity of corrective saccades showed positive correlation with metabolism in bilateral inferior parietal lobe and inferior part of the frontal eye field. All paradigms of smooth pursuit showed positive association with glucose metabolism in V5.Conclusions: Ocular motor functions in PSP are correlated with neuronal activity in distinct anatomical regions. These include the anterior cingulate gyrus (downward gaze palsy), rostral cerebellum (saccades), oculomotor vermis (optokinetic reflex) and inferior parietal as well as temporal regions and frontal eye field (smooth pursuit). These findings provide a deeper insight into the pathophysiology of PSP-associated ocular motor abnormalities. (C) 2014 Elsevier Ltd. All rights reserved.