Critical size of kidney stone through ureter: A mechanical analysis
Critical size of kidney stone through ureter: A mechanical analysis
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通过输尿管肾结石的临界尺寸：机械分析
DOI：
10.1016/j.jmbbm.2022.105432
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发表时间：
2022-11-01
影响因子：
3.9
通讯作者：
Lu，Tian Jian
中科院分区：
文献类型：
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作者：
Liu，Yonggang;Li，Moxiao;Lu，Tian Jian
肾结石引起的输尿管梗阻，伴随着剧烈的疼痛/感染，是一种发病率很高的泌尿系统疾病，已受到广泛关注。目前，在临床上，直径小于0.5mm的肾结石被认为能够通过输尿管。然而，这一临界尺寸（0.5mm）是基于经验的，缺乏定量分析。在本研究中，我们提出了一个结石-输尿管相互作用模型，以定量估计肾结石通过输尿管的临界尺寸。肾结石的临界大小与输尿管大小有关，约大于输尿管内径的11%~ 22%。此外，基于Winkler弹性地基梁模型，我们开发了一个简化的结石-输尿管相互作用模型，以评估这个临界尺寸是如何依赖于输尿管的刚度和肾结石的表面粗糙度。该模型可以帮助泌尿科医生提高个性化诊断和治疗的准确性。
Blockage of ureter caused by kidney stone, accompanied by severe pain/infections, is a high incidence urinary tract disease that has received extensive attention. Currently, in clinics, a kidney stone with diameter less than ∼5 mm is considered capable of passing through ureter. However, this critical size (∼5 mm) is empirically based, lacking quantitative analysis. In this study, we proposed a stone-ureter interaction model to quantificationally estimate the critical size of kidney stone passing through ureter. We revealed that the critical size of kidney stone is related to ureter size, about 11%–22% larger than the inner diameter of ureter. Further, based upon the Winkler elastic foundation beam model, we developed a simplified stone-ureter interaction model to evaluate how this critical size is dependent upon the stiffness of ureter and the surface roughness of kidney stone. The proposed model may help urologists improve the accuracy of personalized diagnosis and treatment.