Do fast neutrons at low dose rate enhance cell transformation in vitro? A basic problem of microdosimetry and interpretation.
Do fast neutrons at low dose rate enhance cell transformation in vitro? A basic problem of microdosimetry and interpretation.
复制标题
低剂量率的快中子是否能增强体外细胞转化？
DOI：
10.1080/09553008514550971
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发表时间：
1985
影响因子：
2.6
通讯作者：
Barendsen Gw
中科院分区：
文献类型：
--
作者：
Barendsen Gw
作者讨论了希尔、汉和埃尔金德的快速传播所带来的口译问题。生物学：1984，46，11 - 15）"低剂量率下的裂变谱中子增强线性低剂量区域（0 - 10 cGy）中的肿瘤转化"，并且质疑单细胞中辐射效应的频率与剂量的线性相关性的简单解释，该简单解释由端点由电离粒子的单径迹引起的假设提供。他指出，这种解释与在低剂量高l.e.t.下观察到的剂量率效应不一致。辐射，并讨论了这种影响的其他解释。
The author discusses the problems of interpretation presented by the rapid communication of Hill, Han and Elkind (Int. J. Radiat. Biol., 1984,46,11-15) 'Fission-spectrum neutrons at low dose rate enhance neoplastic transformation in the linear low dose region (0-10 cGy)', and disputes the simple interpretation of a linear dependence of the frequency of radiation effects in single cells on the dose, provided by the assumption that the endpoint is caused by single tracks of ionizing particles. He points out that this interpretation is inconsistent with the observation of a dose rate effect at low doses of high l.e.t. radiation, and discusses other explanations of this effect.