Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats
Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats
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前列腺素D2对去势大鼠股骨骨密度的影响
DOI：
10.1007/bf00571334
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发表时间：
1993
影响因子：
4.2
通讯作者：
H. Tamaki
中科院分区：
文献类型：
--
作者：
T. Takagi;Tatsuro Yamamoto;Sestuko Asano;H. Tamaki
本实验研究了前列腺素D2（prostaglandin D2，PGD2）对去卵巢（ovariectomy，OVX）和假手术（shamoperative）大鼠股骨骨密度（bonemineraldensity，BMD）等相关参数的影响。术后36天和112天用双能X线骨密度仪（DXA）测量骨密度。当在手术时使用9或10周龄大鼠时，股骨BMD在这些期间增加。卵巢切除术导致股骨近端和远端BMD的稳定增加受到明显抑制。在第1天和第21天皮下注射PGD2缓释制剂不仅可以防止卵巢切除术引起的BMD抑制，而且还可以增强假手术大鼠BMD的稳定增加。第70天开始给药时，BMD增加率的下降恢复到对照水平。血清降钙素（CT）和甲状旁腺激素（PTH）水平不受卵巢切除术或PGD2管理。体重和骨长度增加，但子宫重量减少卵巢切除术。PGD2给药对这些参数无影响。卵巢切除术后空腹尿羟脯氨酸排泄量显著增加，PGD2给药对该参数也无显著影响。这些结果表明，PGD2给药预防OVX大鼠骨质减少和增加假手术和OVX后大鼠的BMD是由于其对骨形成的刺激作用。
SummaryWe studied the effects of prostaglandin D2 (PGD2) on the femoral bone mineral density (BMD) and other related parameters in ovariectomized (OVx) and shamoperated rats. BMD was measuredin vivo by dual energy X-ray absorptiometry (DXA) for the period of 36 days or 112 days after operation. When 9- or 10-week-old rats were used at the time of operation, the femoral BMD increased during these periods. Ovariectomy resulted in a marked suppression of this steady increase in BMD at both proximal and distal ends of the femur. Subcutaneous administration of a slow-release preparation of PGD2 on days 1 and 21 not only prevented the ovariectomy-induced suppression of BMD, but also augmented the steady increase in BMD of the shamoperated rats. When medication was started on day 70, the depressed rate of increase in BMD was restored to the control level. Serum calcitonin (CT) and parathyroid hormone (PTH) levels were not affected by either ovariectomy or by PGD2 administration. Body weight and bone length were increased, but uterine weight was decreased by ovariectomy. PGD2 administration showed no effects on these parameters. There was a significant increase in the fasting level of urinary hydroxyproline excretion after ovariectomy, and PGD2 administration had no significant effect on this parameter either. These results indicate that the prevention of osteopenia in OVx rats and the increase in BMD in shamoperated and post-OVx rats by PGD2 administration are due to its stimulatory effect on bone formation.
环戊烷环的改变对前列腺素骨吸收活性的影响。
DOI：
10.1016/0090-6980(89)90059-2
发表时间：
1989
期刊：
Prostaglandins
影响因子：
--
作者：
Raisz,LG;Woodiel,FN
通讯作者：
Woodiel,FN
前列腺素 E2 可预防大鼠卵巢切除引起的松质骨丢失。
DOI：
10.1016/0169-6009(92)90843-3
发表时间：
1992
期刊：
Bone and mineral
影响因子：
--
作者：
Ke,HZ;Li,M;Jee,WS
通讯作者：
Jee,WS
通过密度梯度分离和培养来自鸡颅盖的两个细胞群：培养和共培养中细胞的前列腺素合成。
影响因子：
4.8
作者：
Yang,CY;Gonnerman,WA;Menconi,M;Taylor,L;Polgar,PR
通讯作者：
Polgar,PR