Miniature hygrometric hot flash recorder
Miniature hygrometric hot flash recorder
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DOI：
10.1016/j.fertnstert.2006.11.184
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发表时间：
2007-08-01
影响因子：
6.7
通讯作者：
Wasson, Samuel
中科院分区：
文献类型：
--
作者：
Freedman, Robert R.;Wasson, Samuel
目的：设计一种既不用电极又不用凝胶的微型便携式潮热记录仪。设计：在第一项研究中，将使用相对湿度传感器记录的推定潮热与患者事件标记进行比较。在第二项研究中，相对。将使用完整的原型记录器记录的湿度与在Biolog记录器上进行的胸骨皮肤电导记录以及事件标记进行比较。地点：大学医学中心。患者：10名健康绝经后女性，报告频繁潮热且未使用药物。干预（S）：实验室中的身体加热。主要结果测量：阳性预测值（PPV），灵敏度，特异性。结果：在两项实验室研究中，所有三项指标（相对湿度、皮肤电导水平、事件）的PPV、灵敏度和特异性均为100%。在现场，相对湿度增加3%每分钟相比，皮肤电导水平检测潮热产生的PPV为95.6%，特异性为95.2%，灵敏度为90.9%。结论（S）：该器械应可用作潮热治疗临床试验的终点。（Fertil Steril（（R））2007;88：494-6. (c)2007年，美国生殖医学会（American Society for Reproductive Medicine）。
Objective: To design and test a miniature ambulatory hot flash recorder that uses neither electrodes nor gel. Design: In the first study, putative hot flashes recorded by using a relative humidity sensor were compared with patient event marks. In the second study, relative. humidity recorded by using a complete prototype recorder was compared with sternal skin conductance recordings made on a Biolog recorder, as well as with event marks. Setting: University medical center. Patient(s): Ten healthy postmenopausal women reporting frequent hot flashes and using no medication. Intervention(S): Body heating in laboratory. Main Outcome Measure(s): Positive predictive value (PPV), sensitivity, specificity. Result(s): In both laboratory studies, the PPV, sensitivity, and specificity among all three measures (relative humidity, skin conductance level, event) were 100%. In the field, a relative humidity increase of 3% per minute compared with skin conductance level-detected hot flashes yielded a PPV of 95.6%, a specificity of 95.2%, and a sensitivity of 90.9%. Conclusion(S): This device should be useful as an endpoint in clinical trials of treatments for hot flashes. (Fertil Steril((R)) 2007;88:494-6. (c) 2007 by American Society for Reproductive Medicine.).