A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury
A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury
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DOI：
10.1016/s0006-8993(99)01564-4
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发表时间：
1999-07-24
期刊：
影响因子：
2.9
通讯作者：
Karmally, S
中科院分区：
文献类型：
--
作者：
Eaton, MJ;Martinez, MA;Karmally, S
为了研究神经病理性疼痛是否对脊髓GABA水平敏感，在神经损伤后鞘内注射GABA，并对感觉行为进行评估。在最高剂量的GABA下，温度和触觉过敏都被永久性地逆转。然而，如果在神经损伤后2-3周内注射GABA，则对预防这种超敏反应无效。这表明，脊髓GABA水平的改变有助于慢性神经病理性疼痛的诱导期，早期干预恢复GABA可能会阻止这种疼痛的发展。(C)1999 Elsevier Science B.V.保留所有权利。
To investigate whether neuropathic pain is sensitive to spinal GABA levels, GABA was injected intrathecally after nerve injury and sensory behaviors were evaluated. Both thermal and tactile hypersensitivities were permanently reversed at the highest doses of GABA. However, if GABA was injected any later than 2-3 weeks after nerve injury, it was ineffective to prevent such hypersensitivity. This suggests that altered spinal GABA levels contribute to the induction phase of chronic neuropathic pain and that early intervention to restore GABA may prevent the development of that pain. (C) 1999 Elsevier Science B.V. All rights reserved.