The evolutionary origin of bilaterian smooth and striated myocytes
The evolutionary origin of bilaterian smooth and striated myocytes
复制标题
DOI：
10.7554/elife.19607
复制
发表时间：
2016-12-01
期刊：
影响因子：
7.7
通讯作者：
Arendt, Detlev
中科院分区：
文献类型：
--
作者：
Brunet, Thibaut;Fischer, Antje H. L.;Arendt, Detlev
平滑肌细胞和横纹肌细胞之间的二分法是两侧对称动物肌肉组织的基础，但其进化起源尚未解决。特别是，内脏平滑肌的相互关系仍不清楚。果蝇和线虫中不存在它们，因此尚未在脊椎动物外对它们进行分子特征鉴定。在这里，我们表征了海洋环节动物 Platynereis dumerilii 肌肉组织的表达谱、超微结构、收缩性和神经支配，并识别了中肠、后肠和心脏周围的平滑肌，这些平滑肌在分子指纹、收缩速度和神经控制方面与脊椎动物相似。我们的数据表明，内脏平滑肌细胞和体细胞横纹肌细胞都存在于原口动物-后口动物祖先中，并且平滑肌细胞后来反复选择横纹收缩模块，例如在脊椎动物心脏进化中。在这些平滑肌细胞向横纹肌细胞的转变过程中，传达肌细胞身份的转录因子的核心调节复合物保持不变，反映了细胞类型进化的一般原则
The dichotomy between smooth and striated myocytes is fundamental for bilaterian musculature, but its evolutionary origin is unsolved. In particular, interrelationships of visceral smooth muscles remain unclear. Absent in fly and nematode, they have not yet been characterized molecularly outside vertebrates. Here, we characterize expression profile, ultrastructure, contractility and innervation of the musculature in the marine annelid Platynereis dumerilii and identify smooth muscles around the midgut, hindgut and heart that resemble their vertebrate counterparts in molecular fingerprint, contraction speed and nervous control. Our data suggest that both visceral smooth and somatic striated myocytes were present in the protostome-deuterostome ancestor and that smooth myocytes later co-opted the striated contractile module repeatedly for example, in vertebrate heart evolution. During these smooth-to-striated myocyte conversions, the core regulatory complex of transcription factors conveying myocyte identity remained unchanged, reflecting a general principle in cell type evolution