Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD).

Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD).
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在连续的静脉血液透析(CVVHD)期间,万古霉素水平经常是亚治疗。

DOI:
10.5414/cn106993
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发表时间:
2012-04
影响因子:
1.1
通讯作者:
Berns JS
Berns JS
中科院分区:
医学4区
文献类型:
--
作者:
Wilson FP;Berns JS

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抽象的。连续性肾脏替代治疗(CRRT)常用于重症监护环境中治疗急性肾损伤。在间歇性透析期间或在检查CRRT时血液和透析流速低于常规做法的研究中,确立了许多常用抗生素的给药指南。在此,我们提供的数据表明,在接受CRRT的患者人群中,万古霉素的水平经常低于治疗水平。应教育肾脏病学实习生,使其了解在该人群中抗生素剂量不足的风险。
Abstract. Continuous renal replacement therapy (CRRT) is frequently used in the intensive care setting for the treatment of acute kidney injury. Dosing guidelines for many commonly used antibiotics were established during intermittent dialysis or in studies examining CRRT at lower blood and dialysis flow rates than are used in common practice. Herein we present data demonstrating frequent subtherapeutic levels of vancomycin in a population of patients on CRRT. Nephrology trainees should be educated as to the risks of under-dosing antibiotics in this population.
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