Engineering of a complex organ: progress toward development of a tissue-engineered lung.
Engineering of a complex organ: progress toward development of a tissue-engineered lung.
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DOI：
10.1513/pats.200802-022aw
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发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Cortiella, Joaquin
中科院分区：
文献类型：
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作者：
Nichols, Joan E;Cortiella, Joaquin
尽管在肺工程方面进展缓慢，但最近在使用干细胞或祖细胞导致肺组成部分可靠生产方面的进展，为未来工程肺组织的发展带来了希望。只有通过并行开发有效和功能的组织工程组件，包括上呼吸道和下呼吸道，以及适用于肺部的支架材料，才能实现开发工程肺的目标。随着时间的推移，从开发肺的每个单独组成部分中获得的知识将被整合起来，以允许开发更大的复杂器官结构。为了实现开发用于再生医学的工程肺的目标，需要在支架的设计和生产方面取得许多进步，包括改善生物相容性，改善弹性，更好地控制支架的超微结构和孔隙度。在我们开始实现工程功能肺组织的目标之前，必须开发满足肺解剖和生理需求的新材料。还需要更好地了解促进细胞粘附、迁移、分化、移植物血管化和肺再生的因素。如果我们要严格从工程的角度实际地评估肺组织的产生，那么在数学模型的发展方面取得进展，以检查促进肺形态发生和组织生长的条件，从而进行组织发育的计算研究，也是必要的。很明显，如果我们要最终成功地制造出有临床应用价值的组织，肺组织工程将需要多学科的方法。
Although there has been slow progress in the engineering of the lung, recent advances in the use of stem or progenitor cells leading to the reliable production of component parts of the lung show promise for the future development of engineered lung tissue. Progress toward the goal of developing an engineered lung will only be accomplished through the parallel development of effective and functional tissue-engineered components that include both upper and lower respiratory tract as well as scaffold material suitable for use in the lung. The knowledge acquired from developing each individual component of lung will, over time, be integrated to allow for the development of larger complex organ structures. To accomplish the goal of developing engineered lung for regenerative medicine, many advances will be required in scaffold design and production, including improved biocompatibility, improved elasticity, and better control of scaffold ultrastructure and porosity. Development of new materials designed to meet the anatomic and physiologic needs of the lung must occur before we can begin to realize the goal of engineering functional lung tissue. Better understanding of factors promoting cell adhesion, migration, differentiation, and vascularization of grafts and lung regeneration as a whole is also needed. Advances in the development of mathematical models to examine the conditions that promote lung morphogenesis and tissue growth for computational investigations of tissue development will also be necessary if we are to realistically evaluate the production of lung tissue strictly from the engineering perspective. It is obvious that engineering of lung tissue will require a multidisciplinary approach if we are to eventually succeed in our attempts to produce tissues worthy of clinical application in the future.