Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics
Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics
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DOI：
10.1039/c0gc00229a
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发表时间：
2010-01-01
期刊：
影响因子：
9.8
通讯作者：
Doucet, Henri
中科院分区：
文献类型：
--
作者：
Dong, Jia Jia;Roger, Julien;Doucet, Henri
钯催化的一系列杂芳烃与芳基卤化物的直接2-，4-或5-芳基化反应在环境友好的碳酸盐溶剂中以中等到良好的产率进行。苯并恶唑或噻唑类化合物的产率最高。呋喃、噻吩苯、吡咯、咪唑或异恶唑衍生物的芳基化反应需要更高的反应温度。
The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range of heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. The best yields were obtained using benzoxazole or thiazole derivatives. The arylation of furan, thiophene, pyrrole, imidazole or isoxazole derivatives was found to require a more elevated reaction temperature.