Time trends in asthma and wheeze in Swedish children 1996-2006: prevalence and risk factors by sex
Time trends in asthma and wheeze in Swedish children 1996-2006: prevalence and risk factors by sex
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DOI：
10.1111/j.1398-9995.2009.02105.x
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发表时间：
2010-01-01
期刊：
影响因子：
12.4
通讯作者：
Ronmark, E.
中科院分区：
文献类型：
--
作者：
Bjerg, A.;Sandstrom, T.;Ronmark, E.
背景：最近的数据表明，以前儿童喘息症状的上升趋势在某些地区已经趋于稳定。我们试图调查性别特异性的趋势，喘息，哮喘，过敏性疾病，过敏性致敏和危险因素为weighe.Methods：我们比较了两个人口为基础的队列7至8岁的孩子从同一个瑞典城镇在1996年和2006年使用父母扩大ISAAC问卷。1996年，完成了3 430份（97%）调查问卷，2006年完成了2 585份（96%）调查问卷。结果：1996年2148例（88%）和2006年1700例（90%）儿童接受皮肤点刺试验。结果：尽管变应性致敏增加（20.6- 29.9%，P < 0.01），但目前喘息（P = 0.13）、变应性鼻炎（P = 0.18）和湿疹（P = 0.22）的患病率无显著变化。然而，在男孩中，当前喘息（12.9- 16.4%，P < 0.01），医生诊断的哮喘（7.1- 9.3%，P = 0.03）和哮喘药物使用的患病率增加。在女孩中，当前症状和状况的流行率趋于下降。从1996年到2006年，所有研究的喘息和哮喘的危险因素的患病率在男孩中相对于女孩增加，从而增加了男孩与女孩的患病率比的风险factors.Conclusions：以前报道的增加，目前的喘息指数在瑞典已趋于稳定。由于诊断活动的增加，医生的诊断继续增加。喘息症状的时间趋势在男孩和女孩之间存在差异，男孩当前喘息增加。这似乎可以用观察到的男孩与女孩相比哮喘风险因素的流行率增加来解释。与当前的喘息、鼻炎或湿疹症状相反，过敏性致敏的患病率显著增加。
P>Background:Recent data suggest that the previously rising trend in childhood wheezing symptoms has plateaued in some regions. We sought to investigate sex-specific trends in wheeze, asthma, allergic conditions, allergic sensitization and risk factors for wheeze.Methods:We compared two population-based cohorts of 7 to 8-year olds from the same Swedish towns in 1996 and 2006 using parental expanded ISAAC questionnaires. In 1996, 3430 (97%) and in 2006, 2585 (96%) questionnaires were completed. A subset was skin prick tested: in 1996, 2148 (88%) and in 2006, 1700 (90%) children participated.Results:No significant change in the prevalence of current wheeze (P = 0.13), allergic rhinitis (P = 0.18) or eczema (P = 0.22) was found despite an increase in allergic sensitization (20.6-29.9%, P < 0.01). In boys, however, the prevalence of current wheeze (12.9-16.4%, P < 0.01), physician-diagnosed asthma (7.1-9.3%, P = 0.03) and asthma medication use increased. In girls the prevalence of current symptoms and conditions tended to decrease. The prevalence of all studied risk factors for wheeze and asthma increased in boys relative to girls from 1996 to 2006, thus increasing the boy-to-girl prevalence ratio in risk factors.Conclusions:The previously reported increase in current wheezing indices has plateaued in Sweden. Due to increased diagnostic activity, physician diagnoses continue to increase. Time trends in wheezing symptoms differed between boys and girls, and current wheeze increased in boys. This was seemingly explained by the observed increases in the prevalence of risk factors for asthma in boys compared with girls. In contrast to the current symptoms of wheeze, rhinitis or eczema, the prevalence of allergic sensitization increased considerably.