Optical frequency domain imaging with a rapidly swept laser in the 815-870 nm range
Optical frequency domain imaging with a rapidly swept laser in the 815-870 nm range
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DOI：
10.1364/oe.14.005937
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发表时间：
2006-06-26
期刊：
影响因子：
3.8
通讯作者：
Yun, S. H.
中科院分区：
文献类型：
--
作者：
Lim, H.;de Boer, J. F.;Yun, S. H.
利用一种新型的波长扫描激光光源，实现了800 nm生物成像窗口的光学频域成像。激光输出从815 nm连续调谐到870 nm，重复频率为43.2 kHz，平均功率为7 mW。在生物组织中的轴向分辨率为10微米，峰值灵敏度为96分贝。非洲爪哇的活体成像显示，采集速度为每秒84帧(每帧512条轴线)。这一新的成像技术可能被证明在用于医学诊断的全面视网膜筛查和用于生物学研究的基于造影剂的成像中有用。(C)2006年美国光学学会。
Optical frequency domain imaging (OFDI) in the 800-nm biological imaging window is demonstrated by using a novel wavelength-swept laser source. The laser output is tuned continuously from 815 to 870 nm at a 43.2-kHz repetition rate with 7-mW average power. Axial resolution of 10-mu m in biological tissue and peak sensitivity of 96 dB are achieved. In vivo imaging of Xenopus laevis is demonstrated with an acquisition speed of 84 frames per second (512 axial lines per frame). This new imaging technique may prove useful in comprehensive retinal screening for medical diagnosis and contrast-agent-based imaging for biological investigations. (c) 2006 Optical Society of America.