The information efficacy of a synapse
The information efficacy of a synapse
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DOI：
10.1038/nn826
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发表时间：
2002-04-01
影响因子：
25
通讯作者：
Segev, I
中科院分区：
文献类型：
--
作者：
London, M;Schreibman, A;Segev, I
我们提供了一个功能性的措施，突触信息效能（SIE），以评估突触输入对锋电位输出的影响。SIE是突触前输入和突触后输出锋电位序列共享的互信息。为了估计SIE，我们使用了一种基于压缩算法的方法。该方法检测单个突触输入对突触后尖峰输出的影响，在神经元模型中存在大量的背景突触活动，逐渐增加的现实主义。SIE随着输入突触活动和输出尖峰之间的时间锁定或输出尖峰的平均数量的增加而增加。SIE依赖于突触运作的环境。我们还测量了SIE实验。突触和树突参数对SIE的影响的系统探索提供了一个新的角度来看待突触作为一种通信设备和树突突触告知轴突多少的定量测量。
We provide a functional measure, the synaptic information efficacy (SIE), to assess the impact of synaptic input on spike output. SIE is the mutual information shared by the presynaptic input and postsynaptic output spike trains. To estimate SIE we used a method based on compression algorithms. This method detects the effect of a single synaptic input on the postsynaptic spike output in the presence of massive background synaptic activity in neuron models of progressively increasing realism. SIE increased with increases either in time locking between the input synapse activity and the output spike or in the average number of output spikes. SIE depended on the context in which the synapse operates. We also measured SIE experimentally. Systematic exploration of the effect of synaptic and dendritic parameters on the SIE offers a fresh look at the synapse as a communication device and a quantitative measure of how much the dendritic synapse informs the axon.