Dietary antioxidant intake and its association with cognitive function in an ethnically diverse sample of US adults.
Dietary antioxidant intake and its association with cognitive function in an ethnically diverse sample of US adults.
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DOI：
10.1097/psy.0000000000000129
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发表时间：
2015-01
影响因子：
3.3
通讯作者：
Zonderman AB
中科院分区：
文献类型：
--
作者：
Beydoun MA;Fanelli-Kuczmarski MT;Kitner-Triolo MH;Beydoun HA;Kaufman JS;Mason MA;Evans MK;Zonderman AB
膳食抗氧化剂可以抑制伴随神经变性的反应，从而防止认知障碍。我们描述了饮食中的抗氧化剂与认知功能在一个大的birabolic人口的协会，同时测试适度的性别，种族和年龄和抑郁症状的调解。这是一项横断面分析，纳入了1,274名基线时年龄在30- 64岁之间的成年人（541名男性和733名女性）（平均值±SD：47.5±9.3），参与了巴尔的摩市MD的健康老龄化社区多样性寿命研究（HANDLS）。评估了记忆、语言/言语、注意力、空间、心理速度、执行功能和整体精神状态等领域的认知表现。采用流行病学研究中心抑郁量表（CES-D）的20项量表来测量抑郁症状。通过两次24小时回忆评估膳食摄入量，估计每1,000千卡总类胡萝卜素、维生素A、C和E的每日消耗量。在关键发现中，一个标准差（SD~2.02 mg/1，000 kcal）高维生素E与言语记忆，即时回忆（β=+0.64 0. 19，p=0.001）和更好的语言/言语流畅性表现（β=+0.53 0. 16，p=0.001）得分较高相关，特别是在年轻年龄组中。维生素E摄入量较高的女性（β=+0.68至0.21，p=0.001）在心理速度测试中表现更好。维生素E-文字记忆关联部分由抑郁症状介导（介导比例=13-16%）。总之，未来的队列研究和饮食干预应侧重于饮食维生素E与认知能力下降的关联，特别是在言语记忆、言语流畅性和心理速度方面。
Dietary antioxidants can inhibit reactions accompanying neurodegeneration, and thus prevent cognitive impairment. We describe associations of dietary antioxidants with cognitive function in a large biracial population, while testing moderation by sex, race and age and mediation by depressive symptoms. This was a cross-sectional analysis of 1,274 adults (541 men and 733 women) aged 30–64y at baseline (Mean±SD: 47.5±9.3) in the Healthy Aging in Neighborhoods of Diversity Across the Lifespan Study (HANDLS), Baltimore city, MD. Cognitive performance in the domains of memory, language/verbal, attention, spatial, psychomotor speed, executive function, and global mental status were assessed. The 20-item Center for Epidemiologic Studies Depression Scale (CES-D) scale was used to measure depressive symptoms. Dietary intake was assessed with two 24-hr recalls, estimating daily consumption of total carotenoids, vitamins A, C and E, per 1,000 kcal. Among key findings, one standard deviation (SD~2.02 mg/1,000kcal) higher vitamin E was associated with a higher score on verbal memory, immediate recall, (β=+0.64±0.19, p=0.001) and better language/verbal fluency performance (β=+0.53±0.16, p=0.001), particularly among the younger age group. Women with higher vitamin E intake (β=+0.68±0.21, p=0.001) had better performance on a psychomotor speed test. The vitamin E-verbal memory association was partially mediated by depressive symptoms (proportion mediated=13–16%). In sum, future cohort studies and dietary interventions should focus on associations of dietary vitamin E with cognitive decline, specifically for domains of verbal memory, verbal fluency and psychomotor speed.