Effect of exercise on serum estrogens in postmenopausal women: A 12-month randomized clinical trial
Effect of exercise on serum estrogens in postmenopausal women: A 12-month randomized clinical trial
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DOI：
10.1158/0008-5472.can-03-3393
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发表时间：
2004-04-15
期刊：
影响因子：
11.2
通讯作者：
Schwartz, RS
中科院分区：
文献类型：
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作者：
McTiernan, A;Tworoger, SS;Schwartz, RS
升高的循环雌激素和久坐的生活方式会增加患乳腺癌的风险。运动对久坐不动的绝经后妇女体内循环雌激素的影响尚不清楚。本研究的目的是检查12个月的中等强度运动干预对血清雌激素的影响。我们随机选取了173名生活在华盛顿州西雅图、久坐不动、体重超重（体重指数为24.0 g/m，体脂为33%）、绝经后妇女，年龄50-75岁，未使用激素治疗。区域，并愿意被随机分配到运动干预组或拉伸对照组。运动干预包括设施和家庭运动（45分钟，每周5天，中等强度运动/休闲运动）。共有170名（98.3%）女性完成了这项研究，她们平均每周锻炼171分钟。3个月后，锻炼者的雌酮、雌二醇和游离雌二醇浓度分别下降了3.8%、7.7和8.2%，而对照组的浓度没有变化或增加（P分别= 0.03、0.07和0.02）。在12个月时，效果的方向保持不变，尽管差异不再具有统计学意义。该效果仅限于体脂减少的女性：体脂百分比[通过双能x射线吸收仪（DEXA）测定]下降大于或等于2%的女性在12个月内血清雌二醇、雌二醇和游离雌二醇分别下降11.9%、13.7%和16.7%，具有统计学意义（与对照组相比）。我们得出结论，绝经后妇女12个月的中等强度运动干预导致血清雌激素显著降低。增加体力活动与降低绝经后乳腺癌风险之间的联系可能部分地由对血清雌激素的影响来解释。
Elevated circulating estrogens and a sedentary lifestyle increase risk for breast cancer. The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. The objective of this study was to examine the effects of a 12-nionth moderate-intensity exercise intervention on serum estrogens. We randomly assigned 173 sedentary, overweight (body mass index > 24.0 g/m(2), body fat > 33%), postmenopausal women, ages 50-75 years, not using hormone therapy, living in the Seattle, Washington. area for the next year, and willing to be randomly assigned to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 days/week moderate intensity sports/recreational exercise). A total of 170 (98.3%) women completed the study with exercisers averaging 171 min/week of exercise. After 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and 8.2%, respectively, versus no change or increased concentrations in controls (P = 0.03, 0.07, and 0.02, respectively). At 12 months, the direction of effect remained the same, although the differences were no longer statistically significant. The effect was limited to women who lost body fat: women whose percentage of body fat [by dual energy x-ray absortiometry (DEXA)] decreased by greater than or equal to2% had statistically significant (comparing exercisers versus controls) decreases at 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively. We concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens. The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens.