A plant Shaker-like K+ channel switches between two distinct gating modes resulting in either inward-rectifying or 'leak' current
A plant Shaker-like K+ channel switches between two distinct gating modes resulting in either inward-rectifying or 'leak' current
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DOI：
10.1016/s0014-5793(01)02832-0
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发表时间：
2001-09-14
期刊：
影响因子：
3.5
通讯作者：
Thibaud, JB
中科院分区：
文献类型：
--
作者：
Dreyer, I;Michard, E;Thibaud, JB
在Shaker样植物钾通道中，AKT2是显著的，因为它介导瞬时的“泄漏样”和时间依赖性超极化激活电流。这种独特的门控行为已在非洲爪蟾卵母细胞和COS和中国仓鼠卵巢细胞中进行了分析。全细胞和单通道数据显示，（i）AKT2通道显示两种不同的门控模式，（ii）给定AKT2通道的门控可以从一种模式改变为另一种模式，以及（iii）这种转换在翻译后因子的控制下。这种行为强烈地让人联想到KCNK2通道，最近报道由其磷酸化状态控制。(C)2001年由Elsevier Science B.V.代表欧洲生物化学学会联合会出版。
Among the Shaker-like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous 'leak-like' and time-dependent hyperpolarisation-activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole-cell and single-channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post-translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.