Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain.
Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain.
复制标题
DOI：
10.1177/0193945915610083
复制
发表时间：
2016-03
影响因子：
1.8
通讯作者：
Holden JE
中科院分区：
文献类型：
--
作者：
Wardach J;Wagner M;Jeong Y;Holden JE
No evidence to date shows that lateral hypothalamic (LH) stimulation produces orexin-A mediated antinociception in the spinal cord dorsal horn (SCDH) in a model of neuropathic pain. We conducted experiments to examine the effect of orexin-A-mediated LH stimulation in female rats with chronic constriction injury (CCI) on thermal hyperalgesia. Rats receiving carbachol into the LH demonstrated antinociception on both the left CCI and right non-ligated paws (p < 0.05). Rats were given carbachol in the LH followed by intrathecal injection of the orexin-1 receptor (OX1) antagonist SB-334867, which blocked LH-induced antinociception compared to control groups (p < 0.05) in the left paw, but not in the right paw. These findings support the hypothesis that LH stimulation produces antinociception in rats with thermal hyperalgesia from neuropathic pain via an orexin-A connection between the LH and the SCDH. Identification of this pathway may lead to studies using orexins to manage clinical pain.
登录
查看更多内容
影响因子：
5.2
作者：
Bardoni R;Takazawa T;Tong CK;Choudhury P;Scherrer G;Macdermott AB
通讯作者：
Macdermott AB
影响因子：
3.3
作者：
Jeong, Y.;Holden, J. E.
通讯作者：
Holden, J. E.
影响因子：
3.3
作者：
Antal, M;Petko, M;StormMathisen, J
通讯作者：
StormMathisen, J
影响因子：
4
作者：
Berger, A;Dukes, EM;Oster, G
通讯作者：
Oster, G
影响因子：
2.9
作者：
Holden, JE;Van Poppel, AY;Thomas, S
通讯作者：
Thomas, S