Association between intraocular pressure peaks and progression of visual field loss.
Association between intraocular pressure peaks and progression of visual field loss.
复制标题
眼压峰值与视野丧失进展之间的关联。
DOI：
10.1016/s0161-6420(91)32340-6
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发表时间：
1991
期刊：
影响因子：
13.7
通讯作者：
Viana,MA
中科院分区：
文献类型：
--
作者：
Zeimer,RC;Wilensky,JT;Gieser,DK;Viana,MA
眼压昼夜变化与青光眼视野损害预后的关系尚不清楚。研究了明显的进行性视野丧失与IOP峰值发生之间的关系。在青光眼患者的自然环境中，通过自我眼压计检测压力峰值。研究组包括有和没有进行性视野丧失的强烈迹象的患者，所有患者在眼科医生办公室获得的IOP均为22 mm Hg或更低。发现明显经历进行性视野丧失的患者比视野稳定的患者具有显著更频繁的IOP峰值。统计学评价表明，在视野进行性丧失患病率为30%的人群中，75%的峰值患者具有进行性丧失，75%的无峰值患者没有视野进展。因此，眼内压峰值与视力丧失的明显进展相关，与平均IOP无关。家庭眼压测量似乎是一种有前途的工具，用于识别可能需要加强随访和改变临床管理的视野丧失风险增加的患者。然而，目前的研究必须辅之以前瞻性研究。
Little is known about the relation between diurnal variations of intraocular pressure (IOP) and prognosis for glaucomatous visual field damage. The association between apparent progressive loss of visual field and the occurrence of IOP peaks was studied. Pressure peaks were detected by a self-tonometer in the natural environment of patients with glaucoma. The study groups consisted of patients with and without a strong indication of progressive visual field losses, all with IOPs of 22 mm Hg or less obtained in the ophthalmologist's office. Patients apparently undergoing progressive visual field loss were found to have significantly more frequent IOP peaks than patients with stable visual fields. A statistical evaluation indicated that, in a population with a 30% prevalence of progressive loss of visual field, 75% of the patients with peaks have progressive loss and 75% of those without peaks do not have visual field progression. Intraocular pressure peaks were thus shown to have an association with the apparent progression of vision loss independent of the mean IOP. Home tonometry appeared to be a promising tool for identifying patients at increased risk of developing visual field loss who may require intensified follow-up and an alteration in clinical management. However, the present study must be complemented by a prospective study.