Deregulation of dicer and mir-155 expression in liposarcoma.
Deregulation of dicer and mir-155 expression in liposarcoma.
复制标题
DOI：
10.18632/oncotarget.3201
复制
发表时间：
2015-04-30
期刊：
影响因子：
--
通讯作者：
Tonini G
中科院分区：
文献类型：
--
作者：
Vincenzi B;Iuliani M;Zoccoli A;Pantano F;Fioramonti M;De Lisi D;Frezza AM;Rabitti C;Perrone G;Onetti Muda A;Russo A;Giordano A;Santini D;Dei Tos AP;Tonini G
Liposarcoma (LPS) is the most common soft tissue sarcoma. It has been demonstrated that mir-155 was the most overexpressed miRNA in well-differentiated LPS(WDLPS)/dedifferentiated LPS (DDLPS). The aim of this study is to evaluate the involvement of Dicer, Drosha and mir-155 in development of LPS and their possible role in stratification of different histological subtypes. Dicer, Drosha and mir-155 mRNA levels were analyzed in formalin-fixed paraffin-embedded specimens from patients diagnosed with 62 LPS and compared with samples of adipose tissues of healthy donors. The experimental data were obtained using qRT-PCR comparing Dicer, Drosha and mir-155 expression levels in tumor samples versus normal fat. The tumor samples from LPS patients showed a significantly lower Dicer expression versus normal adipose tissue, while Drosha levels did not differ. Concerning mir155 expression levels, our results demonstrated a significant mir-155 up-regulation in all LPS subtypes versus normal adipose tissue except for WDLS. These findings demonstrate for the first time that Dicer is deregulated in LPS and show that mir-155 is differentially expressed in LPS subgroups and it could be a promising tool to improve LPS disease stratification and differential diagnosis.
登录
查看更多内容
影响因子：
2.4
作者：
Papachristou，Dionysios J.;Rao，Uma N. M.;Kalofonos，Haralabos P.
通讯作者：
Kalofonos，Haralabos P.
影响因子：
7.5
作者：
Flavin, Richard J.;Smyth, Paul C.;O'Leary, John J.
通讯作者：
O'Leary, John J.
影响因子：
5.7
作者：
Karube, Y;Tanaka, H;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
6.4
作者：
Papachristou, Dionysios J.;Sklirou, Emilia;Rao, Uma N. M.
通讯作者：
Rao, Uma N. M.
DOI：
10.1038/oby.2010.257
发表时间：
2011-04
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Neville MJ;Collins JM;Gloyn AL;McCarthy MI;Karpe F
通讯作者：
Karpe F