General and Persistent Effects of High-Intensity Sweeteners on Body Weight Gain and Caloric Compensation in Rats
General and Persistent Effects of High-Intensity Sweeteners on Body Weight Gain and Caloric Compensation in Rats
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DOI：
10.1037/a0016139
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发表时间：
2009-08-01
影响因子：
1.9
通讯作者：
Davidson, T. L.
中科院分区：
文献类型：
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作者：
Swithers, Susan E.;Baker, Chelsea R.;Davidson, T. L.
在一项早期研究中（S. E. Swithers & T. L. Davidson，2008），与给予等量酸奶与葡萄糖混合的老鼠相比，给予固定量混合糖精酸奶饮食的老鼠体重增加更多，并且热量补偿受损。目前的 4 项实验检验了这些发现的普遍性，并证明，当动物食用用替代性高强度甜味剂（安赛蜜；AceK）加甜的酸奶饮食时，以及给予与低脂酸奶热量相似但营养不同的糖精加糖基础饮食（豆泥）时，体重增加也得到了增加。这些研究还扩展了早期的发现，表明在停止糖精饮食并转向葡萄糖甜饮食后，体重差异仍然存在。此外，首次接触用葡萄糖加糖的饮食的大鼠在随后接触糖精加糖的饮食时仍然会增加额外的体重。这些实验的结果支持了这样的假设：甜味和热量结果之间的弱或不可预测的关系可能会导致正能量平衡。
In an earlier work (S. E. Swithers & T. L. Davidson, 2008), rats provided with a fixed amount of a yogurt diet mixed with saccharin gained more weight and showed impaired caloric compensation relative to rats given the same amount of yogurt mixed with glucose. The present 4 experiments examined the generality of these findings and demonstrated that increased body weight gain was also demonstrated when animals consumed a yogurt diet sweetened with an alternative high-intensity sweetener (acesulfame potassium; AceK) as well as in animals given a saccharin-sweetened base diet (refried beans) that was calorically similar but nutritionally distinct from low-fat yogurt. These studies also extended earlier findings by showing that body weight differences persist after saccharin-sweetened diets are discontinued and following a shift to a diet sweetened with glucose. In addition, rats first exposed to a diet sweetened with glucose still gain additional weight when subsequently exposed to a saccharin-sweetened diet. The results of these experiments add support to the hypothesis that exposure to weak or nonpredictive relationships between sweet tastes and caloric consequences may lead to positive energy balance.