EBV-associated lymphomas in adults.
EBV-associated lymphomas in adults.
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DOI：
10.1016/j.beha.2012.01.005
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Wilson WH
中科院分区：
文献类型：
--
作者：
Roschewski M;Wilson WH
EB病毒（EBV）是一种普遍存在的γ-疱疹病毒，感染大多数人，但仅在一小部分中导致危及生命的疾病。不能将病毒维持在潜伏状态的人可发展为不受控制的EBV驱动的淋巴增生性疾病和淋巴瘤。EBV相关淋巴瘤在移植后或HIV/AIDS发生的细胞免疫缺陷患者中具有良好的特征，但在没有明显免疫缺陷的患者中越来越多地被认识到。对这些淋巴瘤的生物学和EBV在淋巴瘤发生中的作用的进一步理解为针对重要信号传导途径的改进疗法和针对EBV病毒抗原的特异性免疫疗法提供了机会。
Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that infects most people but results in life-threatening diseases in only a small subset. Persons who are unable to maintain the virus in its latent state can develop uncontrolled EBV-driven lymphoproliferative disorders and lymphomas. EBV-associated lymphomas are well-characterized in patients with known defects in cellular immunity as occurs post-transplantation or HIV/AIDS but are increasingly recognized in patients without overt immunodeficiencies. Improved understanding of the biology of these lymphomas and the role EBV plays in lymphomagenesis offers the opportunity for improved therapies targeted at important signaling pathways and immunotherapy specific against EBV viral antigens.