Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP).
Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP).
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DOI：
10.1016/j.gie.2010.01.069
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发表时间：
2010-08
影响因子：
7.7
通讯作者：
Kahrilas, Peter J.
中科院分区：
文献类型：
--
作者：
Kwiatek, Monika A.;Pandolfino, John E.;Hirano, Ikuo;Kahrilas, Peter J.
食管胃交界（EGJ）顺应性增加是导致反流量增加的GERD的关键异常。迄今为止，EGJ的膨胀率仅通过基于研究压力计的原型设备进行测量。该研究的目的是通过评估胃食管反流患者和对照组的EGJ，测试内窥镜功能性腔内成像探针（EndoFLIP），这是一种新的商业技术，旨在测量腔内扩张。前瞻性病例-对照系列。三级转诊中心。在常规食管胃十二指肠镜检查期间，研究了20例GERD患者和20例对照组。EndoFLIP通过内窥镜仪器通道，放置在EGJ上。EndoFLIP使用阻抗平面测量法测量充液袋4.6 cm圆柱形段内16个横截面积（CSA）以及相应的袋内压力。以10 ~ 40 ml的容量控制扩张来评估EGJ的扩张率。在两组中，EGJ最不容易扩张的位点通常在裂孔处。作为一个群体，与对照组相比，GERD患者的EGJ扩张率增加了2至3倍，特别是在20至30毫升的扩张体积时，其定量值与先前使用基于气压计的设备的测量值相似。内镜下对EGJ扩张度的估计，皮瓣瓣膜等级，与EndoFLIP测量结果相关性较差。胃食管反流患者的异质性。EndoFLIP在临床内镜检查中测量EGJ膨胀率是可行的。根据这一生理参数对胃食管反流症患者进行分层，有助于识别对药物或手术治疗有反应或无反应的患者亚群。
Increased esophagogastric junction (EGJ) compliance is a key abnormality in GERD leading to increased volumes of reflux. To date, EGJ distensibility has been measured only with investigational barostatbased prototype devices. The aim of the study was to test the endoscopic functional luminal imaging probe (EndoFLIP), a new commercially available technology designed to measure intraluminal distensibility, by assessing the EGJ of GERD patients and controls. Prospective case-control series. Tertiary referral center. Twenty GERD patients and 20 controls studied during a routine esophagogastroduodenoscopy. The EndoFLIP was passed through the endoscopic instrumentation channel and positioned across the EGJ. The EndoFLIP uses impedance planimetry to measure 16 cross-sectional areas (CSA) along with the corresponding intrabag pressure within a 4.6-cm cylindrical segment of a fluid-filled bag. EGJ distensibility was assessed with 10- to 40-mL volume-controlled distentions. In both groups, the least distensible locus at the EGJ was usually at the hiatus. As a group, GERD patients exhibited two- to threefold increased EGJ distensibility compared with controls, particularly at 20- to 30-mL distention volumes, values quantitatively similar to previous measurements with barostat-based devices. The endoscopic estimation of EGJ distensibility, the flap valve grade, correlated poorly with EndoFLIP measurements. Heterogeneity of GERD patients. Measurement of EGJ distensibility with EndoFLIP is feasible during clinical endoscopy. Stratifying GERD patients according to this physiological parameter may facilitate the identification of patient subgroups responsive or unresponsive to medical or surgical treatments.
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影响因子：
24.5
作者：
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通讯作者：
Wallin, L
影响因子：
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作者：
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