Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma
Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma
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DOI：
10.1111/cas.12009
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发表时间：
2012-12-01
期刊：
影响因子：
5.7
通讯作者：
Suzuki, Mikio
中科院分区：
文献类型：
--
作者：
Deng, Zeyi;Hasegawa, Masahiro;Suzuki, Mikio
为了阐明人乳头瘤病毒（HPV）状态和鳞状细胞癌抗原（SCCA）mRNA表达对头颈部鳞状细胞癌（HNSCC）预后的协同影响，采用PCR和实时定量RT-PCR分别测定了121例接受根治性治疗的原发性HNSCC患者中HPV DNA的存在以及SCCA 1和SCCA 2 mRNA的表达。HNSCC中HPVDNA检出率为28.1%（34/121），仅检出高危型（HPV-16、HPV-33、HPV-35和HPV-58）。HPV阳性者的预后明显好于HPV阴性者（P=0.022）。SCCA 2/SCCA 1 mRNA比值升高是疾病复发的独立预测因子（P=0.004）。此外，高SCCA 2/SCCA 1比值（>0.27）的HPV阴性患者的无复发生存率显著低于低SCCA 2/SCCA 1比值的HPV阴性患者（P
To clarify the synergistic influence of human papillomavirus (HPV) status and squamous cell carcinoma antigen (SCCA) mRNA expression on head and neck squamous cell carcinoma (HNSCC) prognosis, HPV DNA presence and SCCA1 and SCCA2 mRNA expression were determined by PCR and quantitative real-time RT-PCR, respectively, in 121 patients with primary HNSCC who were receiving curative treatment. HPV DNA was detected in 28.1% (34/121) of HNSCC cases, and only high-risk types (HPV-16, HPV-33, HPV-35 and HPV-58) were observed. Positive HPV status showed a significantly better prognosis than negative HPV status (P=0.022). An elevated SCCA2/SCCA1 mRNA ratio was an independent predictor of disease recurrence (P=0.004). In addition, HPV-negative patients with a high SCCA2/SCCA1 ratio (>0.27) had a significantly lower recurrence-free survival rate than HPV-negative patients with a low SCCA2/SCCA1 ratio (P