Chitosan-based scaffolds for bone tissue engineering.
Chitosan-based scaffolds for bone tissue engineering.
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DOI：
10.1039/c4tb00027g
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发表时间：
2014-06-07
期刊：
影响因子：
--
通讯作者：
Zhang M
中科院分区：
文献类型：
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作者：
Levengood SL;Zhang M
骨缺损需要移植物来促进愈合是经常发生的，并且是医疗保健中的昂贵问题。壳聚糖是一种可生物降解的天然高分子材料，近年来作为组织工程和再生医学的支架材料引起了人们的广泛关注。壳聚糖作为骨支架材料特别有吸引力，因为它支持成骨细胞的附着和增殖以及矿化骨基质的形成。本文综述了骨组织工程的基本原理以及壳聚糖作为骨缺损修复支架材料的独特性能。我们提出了常见的方法制造和表征壳聚糖支架，并讨论了材料制备和添加聚合物或陶瓷成分或生物分子对壳聚糖支架性能，如机械强度，结构完整性和功能性骨再生的影响。最后，我们强调了最近的进展，开发壳聚糖为基础的支架，增强骨再生能力。
Bone defects requiring grafts to promote healing are frequently occurring and costly problems in health care. Chitosan, a biodegradable, naturally occurring polymer, has drawn considerable attention in recent years as scaffolding material in tissue engineering and regenerative medicine. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of mineralized bone matrix. In this review, we discuss the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration. We present the common methods for fabrication and characterization of chitosan scaffolds, and discuss the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitosan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration. Finally, we highlight recent advances in development of chitosan-based scaffolds with enhanced bone regeneration capability.