Regulation of Hippocampal Firing by Network Oscillations during Sleep.
Regulation of Hippocampal Firing by Network Oscillations during Sleep.
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DOI：
10.1016/j.cub.2016.02.024
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发表时间：
2016-04-04
期刊：
影响因子：
--
通讯作者：
Diba K
中科院分区：
文献类型：
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作者：
Miyawaki H;Diba K
有人假设，清醒会导致更高的神经元放电，增加能量消耗，而睡眠则会使活动恢复到基线水平。睡眠不同阶段的振荡活动模式可能在这一过程中发挥特定的作用，但一直缺乏共识。为了评估海马体中的这些现象，我们记录了大鼠24小时周期内的CA1区神经元，发现它们的放电在清醒时增加，在睡眠时每小时减少11%。清醒和睡眠也不同地影响了低和高放电神经元。有趣的是，通常与皮层可塑性相关的睡眠纺锤波和尖波波纹（SWRs）的发生率预测了随后的放电变化，并且比其他振荡事件更鲁棒。在非快速眼动睡眠期间启动Spectrometry和SWR，但在随后的快速眼动睡眠时期，这些变化被纳入网络。这些发现表明了纺锤波和SWRs的重要作用，并提供了新的证据，证明了非REM和REM睡眠阶段在神经元活动的稳态调节中存在共生关系。
It has been hypothesized that waking leads to higher firing neurons, with increased energy expenditure, and sleep serves to return activity to baseline levels. Oscillatory activity patterns during different stages of sleep may play specific roles in this process, but consensus has been missing. To evaluate these phenomena in the hippocampus, we recorded from region CA1 neurons in rats across the 24-hr cycle and found that their firing increased upon waking, and decreased 11 % per hr across sleep. Waking and sleep also affected lower and higher firing neurons differently. Interestingly, the incidences of sleep spindles and sharp-wave ripples (SWRs), typically associated with cortical plasticity, were predictive of ensuing firing changes and more robustly than were other oscillatory events. Spindles and SWRs were initiated during non-REM sleep yet the changes were incorporated in the network over the following REM sleep epoch. These findings indicate an important role for spindles and SWRs and provide novel evidence of a symbiotic relationship between non-REM and REM stages of sleep in the homeostatic regulation of neuronal activity.