NUCLEOTIDE-SEQUENCE OF YELLOW-FEVER VIRUS - IMPLICATIONS FOR FLAVIVIRUS GENE-EXPRESSION AND EVOLUTION
NUCLEOTIDE-SEQUENCE OF YELLOW-FEVER VIRUS - IMPLICATIONS FOR FLAVIVIRUS GENE-EXPRESSION AND EVOLUTION
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DOI：
10.1126/science.4023707
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
STRAUSS, JH
中科院分区：
文献类型：
--
作者：
RICE, CM;LENCHES, EM;STRAUSS, JH
已经获得了黄热病病毒类型黄病毒的整个RNA基因组的序列。对该序列的检查揭示了10，233个核苷酸的单个长开放阅读框，其可编码3411个氨基酸的多肽。结构蛋白存在于该多聚蛋白的氨基末端780个残基内;开放阅读框的其余部分由非结构病毒多肽组成。这种基因组组织意味着成熟的病毒蛋白是由多蛋白前体的翻译后切割产生的，并对黄病毒RNA复制和该病毒家族与其他RNA病毒的进化关系有影响。
The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.